DUSP7 Antibody
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中文名稱：DUSP7兔多克隆抗體
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貨號：CSB-PA613702ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: Dual specificity protein phosphatase 7 antibody at 10μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 41 kDa
Observed band size: 45 kDa -
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA613702ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613702ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DUSP7 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Dual specificity phosphatase 7 antibody; Dual specificity protein phosphatase 7 antibody; Dual specificity protein phosphatase PYST2 antibody; DUS7_HUMAN antibody; Dusp7 antibody; Jnk Stimulatory Phosphatase 1 antibody; JSP1 antibody; MAP kinase phosphatase X antibody; MKPX antibody; PYST2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dual specificity protein phosphatase 7 protein (160-419AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex.
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基因功能參考文獻：
- While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis. PMID: 28253537
- high levels of Pyst2-L detected in the active state of AML and ALL diseases and in other types of cancer reflect an altered MAPK signaling pathway in such malignant processes PMID: 14576828
- overexpressed in acute myelogenous leukemia PMID: 14674243
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亞細胞定位：Cytoplasm.
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蛋白家族：Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
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組織特異性：Strongly expressed in liver. Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
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數據庫鏈接：
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