DUSP16 Antibody
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中文名稱：DUSP16兔多克隆抗體
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貨號：CSB-PA060192
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Dual specificity phosphatase 16 antibody; Dual specificity protein phosphatase 16 antibody; DUS16_HUMAN antibody; DUSP 16 antibody; DUSP16 antibody; KIAA1700 antibody; MAP kinase phosphatase 7 antibody; MAPK phosphatase 7 antibody; Mitogen activated protein kinase phosphatase 7 antibody; Mitogen-activated protein kinase phosphatase 7 antibody; MKP 7 antibody; MKP-7 antibody; MKP7 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the C-terminal region of Human MKP-7.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
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基因功能參考文獻：
- The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported. PMID: 26988444
- The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci. PMID: 26381291
- analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha PMID: 23926106
- PPARdelta-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK signaling. PMID: 23639976
- Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
- MKP-7, a negative regulator of JNK, regulates VCAM-1 expression in activated endothelial cells through IRF-1 but not GATA6. PMID: 22182512
- DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
- DUSP16 is a new epigenetically regulated determinant of JNK activation in BL. PMID: 20551953
- MKP-7 down-regulates ERK-dependent gene expression by blocking nuclear accumulation of phospho-ERK. PMID: 20122898
- context-dependent role for DUSP16 on cell transformation and apoptosis. PMID: 14586399
- activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation PMID: 15689616
- MKP7 binds beta-arrestin 2 via amino acids 394-443 of MKP7, the same region that interacts with JIP-1 PMID: 15888437
- identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration PMID: 19307591
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亞細胞定位：Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
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蛋白家族：Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
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數據庫鏈接：
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