DRAP1 Antibody, FITC conjugated

說明書

中文名稱：

DRAP1兔多克隆抗體, FITC偶聯(lián)
貨號：

CSB-PA05144C0Rb
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DRAP1 Polyclonal antibody
Uniprot No.：

Q14919
基因名：

DRAP1
別名：

DR1 associated corepressor antibody; DR1 associated protein 1 (negative cofactor 2 alpha) antibody; DR1 associated protein 1 antibody; DR1 associated protein1 antibody; Dr1-associated corepressor antibody; Dr1-associated protein 1 antibody; DRAP 1 antibody; Drap1 antibody; NC 2 alpha antibody; NC 2alpha antibody; NC2 alpha antibody; NC2-alpha antibody; NC2A_HUMAN antibody; Negative co-factor 2-alpha antibody; Negative cofactor 2 alpha antibody; Negative cofactor 2alpha antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Dr1-associated corepressor protein (4-198AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
基因功能參考文獻：
1. Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly. PMID: 12477712
2. physical cooperation between BTAF1 and NC2alpha in TBP regulation PMID: 15509807
3. The global distribution of DRAP1 on promoters was determined. PMID: 17548813
4. provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode PMID: 17994103
5. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

NC2 alpha/DRAP1 family
組織特異性：

Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
數(shù)據(jù)庫鏈接：

HGNC: 3019

OMIM: 602289

KEGG: hsa:10589

STRING: 9606.ENSP00000307850

UniGene: Hs.356742

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