DPH3 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DPH3 Polyclonal antibody
Uniprot No.：

Q96FX2
基因名：

DPH3
別名：

DPH3 antibody; DESR1 antibody; ZCSL2DPH3 homolog antibody; CSL-type zinc finger-containing protein 2 antibody; DelGEF-interacting protein 1 antibody; DelGIP1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DPH3 homolog protein (1-82AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).; Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.
基因功能參考文獻：
1. The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. PMID: 26416425
2. DelGIP1is a binding partner of deafness locus putative guanine nucleotide exchange factor; downregulation of DelGIP1 induced increased extracellular secretion of proteoglycans indicating a possible role for DelGIP1 in the secretion process PMID: 14980502
3. Solution structure of human DESR1, a CSL zinc-binding protein. PMID: 18214955
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

DPH3 family
組織特異性：

Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung.
數據庫鏈接：

HGNC: 27717

OMIM: 608959

KEGG: hsa:285381

STRING: 9606.ENSP00000419599

UniGene: Hs.388087

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