DOK3 Antibody
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中文名稱：DOK3兔多克隆抗體
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貨號：CSB-PA002182
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規格：￥1090
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圖片：
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Western Blot analysis of HepG2 cells using Dok-3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Docking protein 3 antibody; DOK 3 antibody; DOK Like Protein antibody; Dok3 antibody; DOK3_HUMAN antibody; DOKL Pending antibody; Downstream of tyrosine kinase 3 antibody; p62 DOK Like Protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human Dok-3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
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基因功能參考文獻：
- Mutations in DOK3 gene is associated with prostate cancer PMID: 26585945
- DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. PMID: 27265473
- The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters PMID: 23223229
- absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions PMID: 22761938
- Identification of DOK genes as lung tumor suppressors. PMID: 20139980
- The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 and SHIP-1. PMID: 19682241
- findings indicate that Dok-3 sequesters Grb2 from Shc and inhibits the Ras-Erk pathway downstream of PTKs PMID: 16436051
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亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族：DOK family, Type A subfamily
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組織特異性：Expressed in spleen.
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數據庫鏈接：
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