DOHH Antibody

中文名稱：

DOHH兔多克隆抗體
貨號：

CSB-PA880104LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of PC-3 cells with CSB-PA880104LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DOHH Polyclonal antibody
Uniprot No.：

Q9BU89
基因名：

DOHH
別名：

Deoxyhypusine dioxygenase antibody; Deoxyhypusine hydroxylase antibody; Deoxyhypusine hydroxylase/monooxygenase antibody; Deoxyhypusine monooxygenase antibody; Dohh antibody; DOHH_HUMAN antibody; hDOHH antibody; HEAT like (PBS lyase) repeat containing 1 antibody; HEAT like PBS lyase repeat containing antibody; HEAT like repeat containing protein 1 antibody; HEAT-like repeat-containing protein 1 antibody; HLRC1 antibody; MGC4293 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Deoxyhypusine hydroxylase protein (79-159AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DOHH Antibody (CSB-PA880104LA01HU)，的標記方式是Non-conjugated。對于DOHH Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA880104LB01HU	DOHH Antibody, HRP conjugated	ELISA
FITC	CSB-PA880104LC01HU	DOHH Antibody, FITC conjugated
Biotin	CSB-PA880104LD01HU	DOHH Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
基因功能參考文獻：
1. Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX and illustrate its substrate specificity for deoxyhypusine-eIF-5A. PMID: 25865244
2. Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A. PMID: 24843120
3. a novel role for miR-331-3p and miR-642-5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eIF5A activity. PMID: 22908221
4. The structure and function of DOHH are reported. PMID: 16533814
5. analysis of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction PMID: 17213197
6. Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable. PMID: 19706422
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蛋白家族：

Deoxyhypusine hydroxylase family
數據庫鏈接：

HGNC: 28662

OMIM: 611262

KEGG: hsa:83475

STRING: 9606.ENSP00000250937

UniGene: Hs.515064

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