DOCK7 Antibody

中文名稱：

DOCK7兔多克隆抗體
貨號：

CSB-PA836266LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: DOCK7 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 243, 242, 239, 240, 73 kDa
Observed band size: 243 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA836266LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DOCK7 Polyclonal antibody
Uniprot No.：

Q96N67
基因名：

DOCK7
別名：

DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DOCK7 Antibody (CSB-PA836266LA01HU)，的標記方式是Non-conjugated。對于DOCK7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA836266LB01HU	DOCK7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836266LC01HU	DOCK7 Antibody, FITC conjugated
Biotin	CSB-PA836266LD01HU	DOCK7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.
基因功能參考文獻：
1. these results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of coronary artery disease (CAD) and ischemic stroke in the Southern Chinese Han population. PMID: 29454388
2. Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. PMID: 26493351
3. Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases. PMID: 26744084
4. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. PMID: 27018747
5. These observations suggest that loss of DOCK7 function causes a syndromic form of epileptic encephalopathy by affecting multiple neuronal processes. PMID: 24814191
6. Dock7 mediates serum- and HGF-induced glioblastoma cell invasion. PMID: 24518591
7. DOCK7 functions as an essential and downstream regulator of RAGE-mediated cellular migration through the formation of dendritic pseudopodia. PMID: 23254359
8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
9. Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. PMID: 18426980
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相關疾病：

Epileptic encephalopathy, early infantile, 23 (EIEE23)
亞細胞定位：

Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
蛋白家族：

DOCK family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 19190

OMIM: 615730

KEGG: hsa:85440

STRING: 9606.ENSP00000340742

UniGene: Hs.744927

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