DOCK6 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DOCK6 Polyclonal antibody
Uniprot No.：

Q96HP0
基因名：

DOCK6
別名：

Dedicator of cytokinesis protein 6 antibody; Dock6 antibody; DOCK6_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
基因功能參考文獻：
1. acute knockdown of the Adams-Oliver syndrome (AOS) gene DOCK6, coding for a RAC1/CDC42 guanine nucleotide exchange factor, results in strikingly different phenotypes to those generated by genomic DOCK6 disruption. PMID: 27693507
2. this study demonstrates that miR-142-3p is a key regulator of the TGFbeta-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6. PMID: 25832008
3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies PMID: 25824905
4. A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified. PMID: 21820096
相關疾病：

Adams-Oliver syndrome 2 (AOS2)
亞細胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.
蛋白家族：

DOCK family
組織特異性：

Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
數據庫鏈接：

HGNC: 19189

OMIM: 614194

KEGG: hsa:57572

STRING: 9606.ENSP00000294618

UniGene: Hs.591002

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