DOCK5 Antibody

Name: DOCK5 Antibody
Brand: CUSABIO
SKU: CSB-PA875689LA01HU

說明書

產品詳情

標記方式：

Non-conjugated

本頁面中的產品，DOCK5 Antibody (CSB-PA875689LA01HU)，的標記方式是Non-conjugated。對于DOCK5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA875689LB01HU	DOCK5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875689LC01HU	DOCK5 Antibody, FITC conjugated
Biotin	CSB-PA875689LD01HU	DOCK5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
基因功能參考文獻：
1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
2. the potential role of DOCK5 in human obesity PMID: 22595969
3. along with DOCK1, DOCK5 is an important mediator of CrkII/CrkL regulation of Caco-2 spreading and migration on collagen IV. PMID: 19004829
亞細胞定位：

Cytoplasm. Cell membrane.
蛋白家族：

DOCK family
數據庫鏈接：

HGNC: 23476

OMIM: 616904

KEGG: hsa:80005

STRING: 9606.ENSP00000276440

UniGene: Hs.195403

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