DNAJB8 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DNAJB8 Polyclonal antibody
Uniprot No.：

Q8NHS0
基因名：

DNAJB8
別名：

DJ6 antibody; DnaJ (Hsp40) homolog; subfamily B; member 8 antibody; DnaJ homolog subfamily B member 8 antibody; Dnajb8 antibody; DNJB8_HUMAN antibody; mDj6 antibody; MGC33884 antibody; OTTHUMP00000216243 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DnaJ homolog subfamily B member 8 protein (1-232AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
基因功能參考文獻：
1. DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
2. Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells. PMID: 29316077
3. Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. PMID: 24450541
4. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
5. Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma PMID: 22552285
6. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555
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數據庫鏈接：

HGNC: 23699

OMIM: 611337

KEGG: hsa:165721

STRING: 9606.ENSP00000316053

UniGene: Hs.518241

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