DMRT1 Antibody

Name: DMRT1 Antibody
Brand: CUSABIO
SKU: CSB-PA896914LA01HU

說明書

中文名稱：

DMRT1兔多克隆抗體
貨號：

CSB-PA896914LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse lung tissue, Mouse stomach tissue
All lanes: DMRT1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 29, 19 kDa
Observed band size: 40 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA896914LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA896914LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: HL60 whole cell lysate, 293 whole cell lysate, K562 whole cell lysate
All lanes: DMRT1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 29, 19 kDa
Observed band size: 40 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DMRT1 Polyclonal antibody
Uniprot No.：

Q9Y5R6
基因名：

DMRT1
別名：

CT154 antibody; DM domain expressed in testis 1 antibody; DM domain expressed in testis protein 1 antibody; DM domain gene expressed in testis antibody; DMRT 1 antibody; dmrt1 antibody; DMRT1_HUMAN antibody; DMT 1 antibody; DMT1 antibody; Doublesex and mab 3 related transcription factor 1 antibody; Doublesex- and mab-3-related transcription factor 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，DMRT1 Antibody (CSB-PA896914LA01HU)，的標(biāo)記方式是Non-conjugated。對于DMRT1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA896914LB01HU	DMRT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896914LC01HU	DMRT1 Antibody, FITC conjugated
Biotin	CSB-PA896914LD01HU	DMRT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.
基因功能參考文獻(xiàn)：
1. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation. PMID: 26906082
2. The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare. PMID: 26139570
3. The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system. PMID: 25483589
4. These show that DMRT proteins use a unique binding interaction, inserting two adjacent antiparallel recognition helices into a widened DNA major groove to make base-specific contacts. PMID: 26005864
5. Point mutations of DMRT1 may be rarely associated with male infertility. PMID: 24934491
6. The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure PMID: 23555275
7. neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development. PMID: 22939835
8. Meiosis signalling is dysregulated in carcinoma in situ (CIS) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS cells but is down-regulated with further invasive transformation. PMID: 23303528
9. The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis. PMID: 22899867
10. Findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility. PMID: 21551455
11. variants in or near BAK1, DMRT1, TERT-CLPTM1L, and KITLG predispose to familial and bilateral TGCT. PMID: 21617256
12. There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content PMID: 21462105
13. Chromosome 9p loss is the hallmark of squamous cell carcinoma, and DMRT1, DMRT3 and DOCK8 genes at 9p24.3 might be of interest for the study of the pathophysiology of SCC as potential targets for therapeutic measures. PMID: 20596660
14. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer. PMID: 20543847
15. Analysis of germ cell tumors reveals gene expression changes correlated to DMRT1 levels. PMID: 20007774
16. Comparison of genomic and mRNA sequences show that DMRT1b and c result from exonization of intronic sequences, including the exonization of an Alu element. All 99 Alu elements are non-randomly distributed among the non-coding regions on both directions. PMID: 16617334
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相關(guān)疾病：

Testicular germ cell tumor (TGCT); 46,XY sex reversal 4 (SRXY4)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

DMRT family
組織特異性：

Testis-specific. Expressed in prostate cancer (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 2934

OMIM: 154230

KEGG: hsa:1761

STRING: 9606.ENSP00000371711

UniGene: Hs.98586

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