DLX4 Antibody

說明書

中文名稱：

DLX4兔多克隆抗體
貨號：

CSB-PA002156
規(guī)格：

￥1090
圖片：
Western Blot analysis of COLO205 cells using Dlx-4 Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q92988
基因名：

DLX4
別名：

Beta protein 1 antibody; BP1 antibody; Distal less homeo box 7 antibody; Distal less homeo box 9 antibody; distal-less homeobox 4 antibody; DLX4 antibody; DLX4_HUMAN antibody; DLX7 antibody; DLX8 antibody; DLX9 antibody; Homeobox protein DLX-4 antibody; Homeobox protein DLX-7 antibody; Homeobox protein DLX-8 antibody; Homeobox protein DLX4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Dlx-4.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
基因功能參考文獻(xiàn)：
1. Beta protein 1 (BP1) binds to and regulates estrogen receptor. PMID: 27449292
2. study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients PMID: 26485746
3. Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. PMID: 26325005
4. Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. PMID: 26208636
5. DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer PMID: 26067154
6. This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts PMID: 25954033
7. DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. PMID: 25924901
8. Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. PMID: 25614457
9. indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis PMID: 26524685
10. a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR-122-induced inhibition of proliferation in the HCC cell line Hep3B. PMID: 25823567
11. DLX4 can functionally replace c-MYC. PMID: 25471527
12. Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer. PMID: 25825198
13. DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis PMID: 24947980
14. The results suggest that high expression of DLX4 predicts hepatocellular carcinoma prognosis. PMID: 24824934
15. All trans retinoic acid can inhibit the proliferation and the expression of BP1 in breast cancer cells. PMID: 23158431
16. DLX4 induces cancer cells to undergo epithelial to mesenchymal transition through TWIST, enhancing tumor migration, invasion and metastasis. PMID: 23091415
17. findings suggest that decreased expression of homeobox protein DLX-4 leads to the pathogenesis of preeclampsia by inhibiting epithelial-mesenchymal transition in trophoblasts PMID: 21602546
18. The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta. PMID: 21297662
19. BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. PMID: 11909945
20. involvement of BP1 in the mechanism of the negative regulation of beta-globin transcription. PMID: 15308321
21. BP1 can negatively modulate adult beta-globin gene expression and definitive erythroid cell differentiation, and suggest that BP1 could play a role in thalassemia. PMID: 17003054
22. Increased expression of homeobox gene DLX4 may be a contributing factor to the developmental abnormalities seen in the FGR-affected placentae. PMID: 17062780
23. we were able to show that enforced expression of the DLX4 homeobox gene markedly inhibited in vitro motility and invasion as well as in vivo metastasis via both hematogenous and lymphogenous routes. PMID: 17260014
24. results support the notion that BP1 might contribute to breast neoplastic transformation or tumor progression and suggest for the first time that BP1 mRNA level has potential as a prognostic predictor for breast cancer PMID: 17999690
25. BP1 may regulate bcl-2 and c-myc expression PMID: 18026954
26. BP1 may be part of a pathway contributing to non-small cell lung cancer (NSCLC) development and/or progression and mRNA level could be a novel prognostic marker for NSCLC. PMID: 18420035
27. BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or invasion. PMID: 18931648
28. Other mechanisms in addition to gene amplification play a role in BP1 protein expression om breast camcer/ PMID: 18992636
29. High BP1 expression is associated with inflammatory breast cancer and tumor aggressiveness PMID: 19242057
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相關(guān)疾病：

Non-syndromic orofacial cleft 15 (OFC15)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

Distal-less homeobox family
組織特異性：

Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
數(shù)據(jù)庫鏈接：

HGNC: 2917

OMIM: 601911

KEGG: hsa:1748

STRING: 9606.ENSP00000240306

UniGene: Hs.591167

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