DLX3 Antibody
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中文名稱：DLX3兔多克隆抗體
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貨號：CSB-PA091139
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規格：￥2024
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圖片：
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Western blot analysis of extracts from 293 cells, using DLX3 antibody. -
Immunohistochemistry analysis of paraffin-embedded human heart tissue using DLX3 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DLX3 Polyclonal antibody
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Uniprot No.：
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基因名：DLX3
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human DLX3.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
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基因功能參考文獻：
- our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. PMID: 28515447
- Our research of DLX3 mutation protecting aging-related bone loss opens the possibility of its therapeutic potential in bone regeneration and bone loss disease. PMID: 27924851
- DLX3 expression specifically modulates regulatory networks such as Wnt signaling, phosphatase activity and cell adhesion. PMID: 28186503
- Novel de novo mutation of DLX3 significantly decreases the proliferation rate and inhibits the odontogenic differentiation and mineralization of hDPCs, suggesting that this novel mutation of DLX3 can influence the dentinogenesis in TDO syndrome. PMID: 28135572
- DLX3 regulates bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. PMID: 28963438
- Data establish the DLX3-p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 is a modulator of skin carcinogenesis. PMID: 26522723
- Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities. PMID: 27996093
- We showed that the supplementation of the osteogenic differentiation medium with PTHrP inhibited the alkaline phosphatase activity and the expression of the transcription factor DLX3, but the depletion of PTHrP did not support the differentiation of DFCs.We showed that SUFU (Suppressor Of Fused Homolog) was not regulated during the osteogenic differentiation in DFCs PMID: 27368119
- we identified a recurrent 2-bp deletion in the DLX3 gene in a new family and described their mild clinical phenotype related to the DLX3 mutation. PMID: 26762616
- genetic analysis revealed a novel de novo missense mutation c.533A>G (p.Q178R) in the conserved homeodomain of the DLX3 gene. This DLX3 mutation is the sixth causative mutation for TDO to be identified so far. PMID: 26104267
- ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. PMID: 26674964
- Results suggest that Dlx3 is a novel target of PKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating its stability and function. PMID: 24924519
- rs2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese children. T and C alleles of rs2278163 SNP may potentially be involved in caries susceptibility and caries protection respectively. PMID: 25247779
- In conclusion, results of our study suggest that the NOTCH-signaling pathway, which is activated during the osteogenic differentiation of DFCs. PMID: 24321094
- DLX3 orchestrates the expression of multiple regulators of trophoblast differentiation and that expression of these regulatory genes is abnormal in fetal growth restriction. PMID: 23831639
- DLX3 stimulates osteogenic differentiation via BMP2 dependent pathway. PMID: 22107079
- Increased DLX3 expression in idiopathic fetal growth restricion (FGR) may contribute to trophoblast dysfunction observed in FGR. PMID: 22113468
- DLX3 acts upstream of syncytin, 3beta-hydroxysteroid dehydrogenase, and the human gonadotropin beta-subunit to play a regulatory role in villous cytotrophoblast differentiation. PMID: 21802725
- DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes PMID: 21252474
- In cells expressing equal amounts of mutant and wild-type DLX3, deltaNp63alpha protein level was efficiently regulated, implying that heterozygosity at the DLX3 locus protects tricho-dento-osseous patients from severe p63-associated skin defects. PMID: 21520071
- SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity. PMID: 21268066
- Nuclear expression for DLX3 was observed in villous cytotrophoblasts, syncytiotrophoblast and extravillous cytotrophoblast in the proximal regions of the cytotrophoblast cell columns in first trimester placental tissues. PMID: 20542333
- A genetic investigation revealed a de-novo mutation in the DLX3 gene on chromosome 17q21. PMID: 20151948
- Enamel hardness with 2-bp del in DLX3 was about 53% normal enamel hardness. Mutant enamel thickness was about 50% normal thickness. Calcium level in enamel with 2-bp del was slightly decreased; magnesium level was slightly increased, compared to normal. PMID: 19608154
- AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
- Genomic structure and functional control of the Dlx3-7 bigene cluster PMID: 11792834
- Overexpression of C/EBP beta was sufficient to increase basal expression of a Dlx3 reporter gene in a dose-dependent manner. PMID: 14670999
- results suggest that DLX3 gene is important in bone formation and/or homeostasis of the appendicular skeleton PMID: 15454107
- This is the first report of a mutation within the homeodomain of DLX3. PMID: 15666299
- p63 and Dlx play central roles in embryonic patterning and regulation of different developmental processes, and their mutations have been associated with ectodermal dysplasias [review] PMID: 16187309
- mutation has positive effects on bone density throughout life PMID: 16301156
- DLX-3 gene expression was increased in dental follicle cells during osteogenic differentiation. PMID: 16467978
- Smad6 appears to functionally interact with Dlx3, altering the ability of Dlx3 to bind target gene promoters. PMID: 16687405
- gene defect of trichodentoosseous syndrome has been localized only in the DLX3 gene PMID: 17559453
- Results show that differential DLX3 methylation could be a new epigenetic marker for genotypic B-cell leukemia subgroup with high-risk features. PMID: 17611665
- Carboxy-terminus of the DLX3 protein is critical in determining its function during development in hair, tooth, and bone. PMID: 18203197
- The identified mutation was c.561_562delCT mutation in the DLX3 gene. This study clearly showed that the c.561_562delCT mutation had not only enamel defects, but also other clinical phenotypes resembling those of TDO syndrome. PMID: 18362318
- DLX3(TDO) has a dominant negative effect on DLX3(WT) transcriptional activity PMID: 18492670
- Dlx3 triggers p63 protein degradation by a proteasome-dependent pathway. PMID: 19282665
- results suggest that a serine residue in the homeodomain of the mouse Dlx3 protein can be directly phosphorylated by a protein kinase C-dependent pathway, which affects the DNA binding activity of Dlx3. PMID: 11343707
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相關疾病：Trichodentoosseous syndrome (TDO); Amelogenesis imperfecta 4 (AI4)
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亞細胞定位：Nucleus.
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蛋白家族：Distal-less homeobox family
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