DIS3L2 Antibody

中文名稱：

DIS3L2兔多克隆抗體
貨號：

CSB-PA818258LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human ovarian tissue using CSB-PA818258LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA818258LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DIS3L2 Polyclonal antibody
Uniprot No.：

Q8IYB7
基因名：

DIS3L2
別名：

DI3L2_HUMAN antibody; DIS3 L2 antibody; DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody; DIS3 mitotic control homolog like 2 antibody; DIS3-like exonuclease 2 antibody; Dis3l2 antibody; FLJ36974 antibody; MGC42174 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DIS3-like exonuclease 2 protein (201-400AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DIS3L2 Antibody (CSB-PA818258LA01HU)，的標記方式是Non-conjugated。對于DIS3L2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA818258LB01HU	DIS3L2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA818258LC01HU	DIS3L2 Antibody, FITC conjugated
Biotin	CSB-PA818258LD01HU	DIS3L2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
基因功能參考文獻：
1. The evidence has been presented that Dis3l2 controls miRNA-9 production. PMID: 27881476
2. Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs PMID: 27647875
3. Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease. PMID: 27911720
4. these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis. PMID: 27431325
5. DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation. PMID: 26809675
6. DIS3L2 is the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. PMID: 24141620
7. in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division PMID: 23613427
8. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. PMID: 22306653
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相關疾病：

Perlman syndrome (PRLMNS)
亞細胞定位：

Cytoplasm. Cytoplasm, P-body.
蛋白家族：

RNR ribonuclease family, DIS3L2 subfamily
數據庫鏈接：

HGNC: 28648

OMIM: 267000

KEGG: hsa:129563

STRING: 9606.ENSP00000315569

UniGene: Hs.732236

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