DESI2 Antibody

說明書

產品詳情

Uniprot No.：

Q9BSY9
基因名：

DESI2
別名：

DESI2 antibody; C1orf121 antibody; FAM152A antibody; PPPDE1 antibody; CGI-146 antibody; PNAS-4 antibody; Deubiquitinase DESI2 antibody; EC 3.4.19.12 antibody; Desumoylating isopeptidase 2 antibody; DeSI-2 antibody; PPPDE peptidase domain-containing protein 1 antibody; Protein FAM152A antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PPPDE1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
基因功能參考文獻：
1. The PPPDE1 could mediate the ubiquitin chain editing of RPS7, deubiquitinating Lys 48-linked ubiquitination, and finally stabilize RPS7 proteins. PMID: 28483520
2. DESI2 may influence the AKT/mTOR signal in pancreatic cancer. PMID: 25079376
3. findings suggest a novel mechanism by which elevated PNAS-4 first causes DNA-dependent protein kinase-mediated Chk1/2 activation and then results in inhibition of the Cdc25A-CDK2-cyclin E/A pathway PMID: 25918161
4. hPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A-Cdk2-Cyclin E/Cyclin A axis and mitochondrial dysfunction-mediated caspase-dependent and -independent apoptotic pathways. PMID: 23322088
5. PNAS-4 is not a p53 target, but overexpression of PNAS-4 is correlated to p53 inactivity in colorectal cancer. PMID: 21556770
6. overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells. PMID: 19133312
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亞細胞定位：

Cytoplasm.
蛋白家族：

DeSI family
數據庫鏈接：

HGNC: 24264

OMIM: 614638

KEGG: hsa:51029

STRING: 9606.ENSP00000306528

UniGene: Hs.498317

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