DEFB126 Antibody

中文名稱：

DEFB126兔多克隆抗體
貨號(hào)：

CSB-PA866323LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA866323LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DEFB126 Polyclonal antibody
Uniprot No.：

Q9BYW3
基因名：

DEFB126
別名：

DEFB126 antibody; C20orf8 antibody; DEFB26Beta-defensin 126 antibody; Beta-defensin 26 antibody; DEFB-26 antibody; Defensin antibody; beta 126 antibody; Epididymal secretory protein 13.2 antibody; ESP13.2 antibody; HBD26 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Beta-defensin 126 protein (36-111AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，DEFB126 Antibody (CSB-PA866323LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DEFB126 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA866323LB01HU	DEFB126 Antibody, HRP conjugated	ELISA
FITC	CSB-PA866323LC01HU	DEFB126 Antibody, FITC conjugated
Biotin	CSB-PA866323LD01HU	DEFB126 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
基因功能參考文獻(xiàn)：
1. Data indicate a significant contribution of the frame-shift polymorphism of defensin beta 126 (DEFB126) rs11467497 to male infertility. PMID: 25721098
2. These results demonstrate that the DEFB126 core peptide has critical functions in parallel to its C-terminal tail by showing LPS-binding activity, anti-inflammatory effects and intracellular regulatory function. In addition, DEFB126 displays antimicrobial activity against E. coli, S. aureus, and C. elegans. PMID: 23229569
3. This review shows how DEFB126 is critical for efficient transport of sperm in the female reproductive tract, preventing their recognition by the female immune system. PMID: 22710670
4. DEFB126 genotype and lectin binding were correlated with sperm performance in the penetration assays. PMID: 21775668
5. Analyses restricted to glioblastoma (n = 254) yielded significant associations for the SELP, DEFB126/127, SERPINI1, and LY96 genetic regions. PMID: 19423540
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相關(guān)疾病：

May be involved in infertility. Homozygosity for frameshift truncating mutations are associated with reduced sperm O-linked glycan content, impaired sperm mobility and a reduced live birth rate (PubMed:21775668, PubMed:25721098). However, for one common mutation the change in sperm sialic acid levels has been challenged (PubMed:26832966).
亞細(xì)胞定位：

Secreted.
蛋白家族：

Beta-defensin family
組織特異性：

High-level and epididymis-specific expression. Expression is down-regulated in infertile men.
數(shù)據(jù)庫鏈接：

HGNC: 15900

KEGG: hsa:81623

STRING: 9606.ENSP00000371835

UniGene: Hs.124211

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