DEFA6 Antibody
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中文名稱：DEFA6兔多克隆抗體
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貨號：CSB-PA980801GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：DEFA6
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別名：alpha 6 antibody; DEF6 antibody; DEF6_HUMAN antibody; DEFA 6 antibody; DEFA6 antibody; Defensin 6 antibody; Defensin alpha 6 antibody; Defensin alpha 6 Paneth cell specific antibody; Defensin antibody; Defensin-6 antibody; HD 6 antibody; HD6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human DEFA6
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
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基因功能參考文獻：
- HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis PMID: 28198610
- alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans PMID: 28026958
- Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease. PMID: 26891258
- Paneth cell alpha-defensin 6 is an antimicrobial peptide. PMID: 25354318
- Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells. PMID: 25158166
- In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer. PMID: 23028900
- study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria PMID: 22722251
- Regions 2, 3 & 9, 10 were more hydrophobic than other regions. It was difficult for the HD molecule to have many conformations because of its 3 S-S bridges; however, it responds to various external factors by restricting conformation. PMID: 21873175
- Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma PMID: 20979654
- defensin alpha6 is highly expressed in colon cancer cell lines PMID: 15613481
- Crystal structure of HD6. PMID: 17088326
- Human enteric defensin (HD)-5 and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia. PMID: 19250512
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亞細胞定位：Secreted.
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蛋白家族：Alpha-defensin family
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組織特異性：Paneth cells of the small intestine.
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數據庫鏈接：
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