DEDD2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q8WXF8
基因名：

DEDD2
別名：

DEDD2 antibody; FLAME3 antibody; PSEC0004DNA-binding death effector domain-containing protein 2 antibody; DED-containing protein FLAME-3 antibody; FADD-like anti-apoptotic molecule 3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human DEDD2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
基因功能參考文獻(xiàn)：
1. FLAME-3 forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
2. DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898
亞細(xì)胞定位：

Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
組織特異性：

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell l
數(shù)據(jù)庫鏈接：

HGNC: 24450

KEGG: hsa:162989

STRING: 9606.ENSP00000470082

UniGene: Hs.515432

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