DDX53 Antibody
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中文名稱：DDX53兔多克隆抗體
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貨號：CSB-PA801951
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA801951(DDX53 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：DDX53
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別名：CAGE antibody; Cancer associated gene protein antibody; Cancer-associated gene protein antibody; Cancer/testis antigen 26 antibody; CT26 antibody; DDX53 antibody; DDX53_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 53 antibody; DEAD box protein 53 antibody; DEAD box protein CAGE antibody; Probable ATP dependent RNA helicase DDX53 antibody; Probable ATP-dependent RNA helicase DDX53 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human DDX53
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 WB 1:200-1:1000 IHC 1:100-1:300 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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基因功能參考文獻：
- A novel role of DDX53 in regulating cancer stem cell-like properties by binding to SOX-2.DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells. PMID: 28535666
- DDX53 promotes stem cell-like properties, autophagy, and confers resistance to anti-cancer drugs in breast cancer cells. PMID: 28152297
- Results provide evidence that miR-30a forms a positive feedback loop with CAGE to regulate the expression of p53 confering resistance to anti-cancer drugs. PMID: 26912082
- miR-217-CAGE feedback loop serves as a target for overcoming resistance to various anti-cancer drugs, including EGFR and HER2 inhibitors. PMID: 26863629
- Results show the direct regulation of CAGE expression by HDAC3 and that HDAC3-CAGE axis regulates the activation of EGFR. HDAC3 targets CAGE to regulate the tumorigenic potential and angiogenic potential of cancer cells. PMID: 26883907
- CAGE induced the interaction between histone deacetylase 2 (HDAC2) and Snail, which exerted a negative effect on p53 expression in neoplastic cells; CAGE confers drug resistance by regulating expression of p53 through HDAC2. PMID: 20534591
- CAGE is expressed in a variety of cancers but not in normal tissues except testis, and might play a role in cellular proliferation. PMID: 11922625
- results suggest that the methylation status of the CpG sites of CAGE determines its expression, and that hypomethylation of CAGE precedes the development of gastric cancer and hepatocellular carcinoma PMID: 12849980
- CAGE promotes motility of cancer cells through activation of focal adhesion kinase (FAK). PMID: 17028776
- Hypomethylated CAGE promoter CpG islands are frequently involved in uterine cervical carcinogenesis. PMID: 17341616
- The CAGE gene is widely expressed in various cancer tissues and cancer cell lines. PMID: 18388483
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亞細胞定位：Nucleus.
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蛋白家族：DEAD box helicase family
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組織特異性：Expressed in testis. Wide expression in various cancer tissues and cancer cell lines.
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數據庫鏈接：
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