DCXR Antibody

說明書

中文名稱：

DCXR兔多克隆抗體
貨號：

CSB-PA006577GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q7Z4W1
基因名：

DCXR
別名：

Carbonyl reductase 2 antibody; Carbonyl reductase II antibody; DCR antibody; Dcxr antibody; DCXR_HUMAN antibody; Dicarbonyl and L xylulose reductase antibody; Dicarbonyl L xylulose reductase antibody; Dicarbonyl/ L xylulose reductase antibody; Dicarbonyl/L-xylulose reductase antibody; HCR2 antibody; HCRII antibody; Human carbonyl reductase 2 antibody; kiDCR antibody; Kidney dicarbonyl reductase antibody; L xylulose reductase antibody; L-xylulose reductase antibody; P34H antibody; PNTSU antibody; SDR20C1 antibody; Short chain dehydrogenase/reductase family 20C member 1 antibody; Sperm surface protein P34H antibody; XR antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human DCXR
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
基因功能參考文獻：
1. Ureaplasma urealyticum infection may affect the level of P34H protein expression on spermatozoa PMID: 28012250
2. identification of DCXR as an enzyme activity mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung PMID: 28595002
3. Low expression of DCXR is associated with hepatocellular carcinoma. PMID: 27658779
4. EGCG is a potential inhibitor to human DCXR. PMID: 23661708
5. combined frequency of the two mutant DCXR alleles in 1,067 Ashkenazi Jewish controls was 0.0173, suggesting a pentosuria frequency of approximately one in 3,300 in this population PMID: 22042873
6. highly expressed in kidney and liver PMID: 11882650
7. crystallization and preliminary crystallographic analysis PMID: 12136162
8. structure of the tetrameric form of human L-Xylulose reductase PMID: 15906319
9. Our results demonstrate that the proportion of positive P34H cases that produced embryos in vitro clearly differs from cases with undetectable levels of P34H (P<.001). PMID: 16616743
10. These results suggested that altered HCR2 expression might play roles in the carcinogenesis and progression of hepatocellular carcinoma. PMID: 16847567
11. A significant proportion of men investigated for male infertility may be epididymal protein P34H deficient. PMID: 17434498
12. Decreased membranous expression of DCXR with altered subcellular localization appears to be associated with malignant progression of melanocytic lesions in human skin. PMID: 17576332
13. DCXR trranfected into mice may function in the removal of renal alpha-dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis. PMID: 18079483
14. DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer. PMID: 18086765
15. The action of human XR may be regulated by cellular redox conditions through reversible disulfide-bond formation and by S-cysteinylation. PMID: 19337691
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相關疾病：

Pentosuria (PNTSU)
亞細胞定位：

Membrane; Peripheral membrane protein.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
數據庫鏈接：

HGNC: 18985

OMIM: 260800

KEGG: hsa:51181

STRING: 9606.ENSP00000303356

UniGene: Hs.9857

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