DCP2 Antibody

中文名稱：

DCP2兔多克隆抗體
貨號：

CSB-PA810265LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA810265LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA810265LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) DCP2 Polyclonal antibody
Uniprot No.：

Q8IU60
基因名：

DCP2
別名：

DCP2 antibody; DCP2 decapping enzyme homolog (S. cerevisiae) antibody; DCP2, S. cerevisiae, homolog of antibody; DCP2_HUMAN antibody; decapping enzyme 2, S. cerevisiae, homolog of antibody; decapping enzyme homolog (S. cerevisiae) antibody; FLJ33245 antibody; hDpc antibody; m7GpppN-mRNA hydrolase antibody; mRNA decapping enzyme 2 antibody; mRNA-decapping enzyme 2 antibody; Nucleoside diphosphate-linked moiety X motif 20 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody; Nudix motif 20 antibody; NUDT20 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human m7GpppN-mRNA hydrolase protein (1-385AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，DCP2 Antibody (CSB-PA810265LA01HU)，的標(biāo)記方式是Non-conjugated。對于DCP2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA810265LB01HU	DCP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA810265LC01HU	DCP2 Antibody, FITC conjugated
Biotin	CSB-PA810265LD01HU	DCP2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
基因功能參考文獻(xiàn)：
1. Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation. PMID: 25870104
2. Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains. PMID: 23115303
3. an mRNA decapping enzyme demonstrated to contain intrinsic decapping activity PMID: 12218187
4. Human Dcp2 is a catalytically active mRNA decapping enzyme that localizes to the cytoplasm PMID: 12486012
5. hDcp2 can specifically bind to and can regulate the stability of a subset of mRNAs PMID: 18039849
6. These data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation. PMID: 18361920
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亞細(xì)胞定位：

Cytoplasm, P-body. Nucleus.
蛋白家族：

Nudix hydrolase family, DCP2 subfamily
組織特異性：

Expressed in brain and testis. Not detected in heart (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 24452

OMIM: 609844

KEGG: hsa:167227

STRING: 9606.ENSP00000373715

UniGene: Hs.443875

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