Chc Antibody

^{Rare Species}

說明書

產品詳情

Uniprot No.：

P29742
基因名：

Chc
別名：

Clathrin heavy chain Chc CG9012
反應種屬：

Drosophila melanogaster (Fruit fly)
免疫原：

Recombinant Drosophila melanogaster (Fruit fly) Chc protein (1-260aa)
免疫原種屬：

Drosophila melanogaster (Fruit fly)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Affinity-chromatography
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
基因功能參考文獻：
1. Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex. PMID: 24718986
2. Results report a Drosophila disabled (DAB)mutant revealing a novel role for DAB proteins in chemical synaptic transmission, and support a role for clathrin-mediated endocytosis in rapid clearance of neurotransmitter release sites. PMID: 21606364
3. Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling. PMID: 20111007
4. chc mRNA and protein are highly expressed from early stages of embryogenesis onwards, consistent with genetic studies predicting a maternal contribution of the gene function PMID: 19577664
5. Chc is critical for synaptic vesicle recycling and in the absence of the protein, bulk retrieval mediates massive synaptic membrane internalization. PMID: 18762582
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亞細胞定位：

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.
蛋白家族：

Clathrin heavy chain family
數據庫鏈接：

KEGG: dme:Dmel_CG9012

STRING: 7227.FBpp0073966

UniGene: Dm.3174

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