CYTH3 Antibody
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中文名稱：CYTH3兔多克隆抗體
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貨號：CSB-PA002833
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規格：￥1090
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圖片：
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Western Blot analysis of COS7 cells using GRP1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CYTH3 antibody; ARF nucleotide-binding site opener 3 antibody; ARNO3 antibody; ARNO3 protein antibody; CYH3_HUMAN antibody; Cyth3 antibody; Cytohesin-3 antibody; General receptor of phosphoinositides 1 antibody; Grp1 antibody; PH antibody; PH, SEC7 and coiled-coil domain-containing protein 3 antibody; Protein ARNO3 antibody; PSCD3 antibody; SEC7 and coiled-coil domain-containing protein 3 antibody; SEC7 homolog C antibody; Sec7-3 antibody; Sec7c antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat,Monkey
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免疫原：Synthesized peptide derived from the C-terminal region of Human GRP1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization.
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基因功能參考文獻：
- Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion. PMID: 24966920
- The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin. PMID: 22454518
- incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells PMID: 21932773
- GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements PMID: 15878955
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亞細胞定位：Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction.
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組織特異性：Almost absent from liver, thymus and peripheral blood lymphocytes.
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數據庫鏈接：
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