CYTH1 Antibody

說明書

中文名稱：

CYTH1兔多克隆抗體
貨號：

CSB-PA933387
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA933387(CYTH1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA933387(CYTH1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q15438
基因名：

CYTH1
別名：

B2 1 antibody; CLM1 antibody; CTH 1 antibody; CYH1_HUMAN antibody; CYTH1 antibody; CYTIP antibody; Cytoadhesin 1 antibody; CYTOHESIN 1 antibody; Cytohesin-1 antibody; D17S811E antibody; FLJ34050 antibody; FLJ41900 antibody; Homolog of secretory protein SEC7 antibody; KIAA4240 antibody; mKIAA4240 antibody; mSec7 1 antibody; OTTHUMP00000196778 antibody; OTTHUMP00000196779 antibody; PH antibody; PH; SEC7 and coiled-coil domain containing protein 1 antibody; Pleckstrin homology Sec7 and coiled/coil domains 1 antibody; Pleckstrin homology Sec7 and coiled/coil domains protein 1 antibody; Pleckstrin homology; Sec7 and coiled coil domains 1 antibody; PSCD1 antibody; SEC7 and coiled-coil domain-containing protein 1 antibody; Sec7 antibody; SEC7 homolog A antibody; SEC7 homolog B2 1 antibody; SEC7 homolog B2-1 antibody; SEC7; yeast; homolog of antibody; Sec7a antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human CYTH1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
基因功能參考文獻(xiàn)：
1. computational study suggests that although curcumin to some extent binds with Tp receptor, yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD activity in PASMCs. PMID: 28780751
2. CYTH1 is a novel major regulator of adhesion and engraftment in human hematopoietic stem and progenitor cells through mechanisms that, at least in part, involve the activation of integrins. PMID: 27899358
3. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling. PMID: 27044754
4. cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells PMID: 22815959
5. findings suggest that cytohesin-1 is a key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on beta2 and beta1 integrin activation PMID: 21511340
6. involvement of cytohesin-1 in the regulation of the functional responses of human PMNs, linked, in part at least, to the activation of Arf6. PMID: 20018626
7. Data show that CYTIP and cytoadhesin-1 are upregulated during dendritic cell maturation. PMID: 12606567
8. findings reveal that mycobacteria promote their uptake through a process of "inside-out" signaling involving CD14, TLR2, PI3K, and cytohesin-1. This converts low avidity CR3 into an active receptor leading to increased bacterial internalization PMID: 15778383
9. demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins PMID: 19346499
10. Phosphorylated cytohesin-1 is able to tightly associate with the actin cytoskeleton, and is required for maximal leukocyte function antigen-1-mediated adhesion of Jurkat cells to Icam-1. PMID: 11438522
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亞細(xì)胞定位：

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell junction, tight junction. Cell junction, adherens junction.
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 9501

OMIM: 182115

KEGG: hsa:9267

STRING: 9606.ENSP00000354398

UniGene: Hs.191215

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