CYP4F12 Antibody
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中文名稱：CYP4F12兔多克隆抗體
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貨號：CSB-PA864033ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: CYP4F12 antibody at 6μg/ml
Lane 1: Mouse small intestine tissue
Lane 2: Rat liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 61, 12 kDa
Observed band size: 61 kDa -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA864033ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA864033ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CYP4F12 Polyclonal antibody
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Uniprot No.：
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基因名：CYP4F12
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別名：CYP4F12; UNQ568/PRO1129; Cytochrome P450 4F12; CYPIVF12
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宿主：Rabbit
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human Cytochrome P450 4F12 protein (265-524AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate. Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids. Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate. Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine.
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基因功能參考文獻：
- These results suggest that human and marmoset P450 3A4/90 and 4F12 in livers or small intestines played important roles in terfenadine t-butyl hydroxylation. Marmosets could be a model for humans during first pass extraction of terfenadine and related substrates. PMID: 28436281
- Our results showed that HCV infection induced expression of CYP4F12 protein, which bound to the HCV replication complex to facilitate viral replication. PMID: 26845356
- We conclude that CYP4F8 and CYP4F12 catalyze epoxidation of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6. PMID: 16112640
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亞細胞定位：Endoplasmic reticulum membrane. Microsome membrane.
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蛋白家族：Cytochrome P450 family
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組織特異性：Expressed in small intestine, liver, colon and heart.
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數據庫鏈接：
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