CYFIP2 Antibody

說明書

產品詳情

Uniprot No.：

Q96F07
基因名：

CYFIP2
別名：

CYFIP2 antibody; KIAA1168 antibody; PIR121Cytoplasmic FMR1-interacting protein 2 antibody; p53-inducible protein 121 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CYFIP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
基因功能參考文獻：
1. Study characterized the functional roles of the two brain-specific phosphorylation sites (S582 and T1067) of CYFIP2 in cultured hippocampal neurons; found that overexpression of the phospho-blocking T1067A mutant significantly decreased the density of stubby spines, but not other types of spines. Study found that T1067 phosphorylation of CYFIP2 could potentially weaken the interaction between CYFIP2 and Nap1. PMID: 28692454
2. Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP interactor, is detected in fragile X syndrome. PMID: 22268788
3. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. PMID: 17245118
亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome.
蛋白家族：

CYFIP family
組織特異性：

Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
數據庫鏈接：

HGNC: 13760

OMIM: 606323

KEGG: hsa:26999

STRING: 9606.ENSP00000325817

UniGene: Hs.519702

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