CXCL6 Antibody

中文名稱：

CXCL6兔多克隆抗體
貨號：

CSB-PA06169A0Rb
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA06169A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA06169A0Rb at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CXCL6 Polyclonal antibody
Uniprot No.：

P80162
基因名：

CXCL6
別名：

C X C motif chemokine 6 antibody; Chemokine (C X C motif) ligand 6 antibody; Chemokine alpha 3 antibody; CKA 3 antibody; CKA-3 antibody; CKA3 antibody; CXCL 6 antibody; CXCL6 antibody; CXCL6_HUMAN antibody; GCP 2 antibody; GCP-2 antibody; Granulocyte chemotactic protein 2 antibody; N-processed variant 3 antibody; SCYB6 antibody; Small inducible cytokine B6 antibody; Small inducible cytokine subfamily B (Cys X Cys) member 6 antibody; Small inducible cytokine subfamily B (Cys X Cys) member b antibody; Small-inducible cytokine B6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human C-X-C motif chemokine 6 protein (38-114AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CXCL6 Antibody (CSB-PA06169A0Rb)，的標記方式是Non-conjugated。對于CXCL6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA06169B0Rb	CXCL6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA06169C0Rb	CXCL6 Antibody, FITC conjugated
Biotin	CSB-PA06169D0Rb	CXCL6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
基因功能參考文獻：
1. CXCL6 could reduce the expression of miR-515-5p in NSCLC cells; MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in non-small cell lung cancer cell cells. PMID: 29136957
2. Study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. PMID: 28811711
3. CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis. PMID: 28507181
4. CXCL6 level is high in the serum of chronic hepatitis B patients.CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFkappaB pathway and inhibits collagen I secretion by hepatic stellate cells. PMID: 27032929
5. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure. PMID: 27520585
6. The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA. PMID: 25993443
7. HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells. PMID: 25323032
8. Expression of the CXCL8, CXCL6 and CXCL1 genes are under the primary control of 1,25-dihydroxyvitamin D3 and its receptor. PMID: 24250750
9. Data suggest that expression of CXCL6 in trophoblasts is up-regulated during pregnancy development/placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2 (matrix metalloproteinase 2). PMID: 23814098
10. Overexpression of GCP-2 in mesenchymal stem cells has the potential to enhance their angiogenic and survival properties. PMID: 22886775
11. Studies show that functional blocking of GCP-2 inhibits tumor growth and metastases. PMID: 21236563
12. The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells. PMID: 20507572
13. The level of expression of granulocyte chemotactic protein 2 correlates with the severity of periodontitis and appears to act as a yet unrecognized functional adjunct to interleukin-8 in pathological gingival tissues. PMID: 18842116
14. results suggest that granulocyte chemotactic protein-2 is an additional ELR(+)-CXC chemokine expressed in endometrial stromal cells PMID: 12524079
15. induction in mesenchymal cells by interleukin-1beta and down-regulation by interferon-gamma PMID: 12533683
16. Neutrophil recruitment to inflammatory sites is mediated by two related receptors: CXCR1 and CXCR2. Both receptors share two ligands, interleukin-8 (CXCL8) and GCP-2 (CXCL6). PMID: 12628493
17. expression in inflamed intestinal tissue in Crohn's disease PMID: 15214047
18. production of GCP-2 by endothelial cells within the tumor can contribute to tumor development through neovascularization due to endothelial cell chemotaxis and to tumor cell invasion and metastasis PMID: 15652347
19. LDL lipoprotein subunit L5 induces human umbilical vein endothelial cells (HUVEC) to express CXCL6. PMID: 17022986
20. These findings indicate that the equilibrium between angiostatic and angiogenic factors during inflammation and tumor progression is rather complex and differs depending on the chemokine, cell type, and stimulus. PMID: 17827342
21. These observations suggest a role for CXCL6 in the innate immune response to microbial invasion of the amniotic cavity. PMID: 18782286
22. Report gonadotropin-releasing hormone-regulated CXCL6 expression in human placentation. PMID: 19369450
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亞細胞定位：

Secreted.
蛋白家族：

Intercrine alpha (chemokine CxC) family
數據庫鏈接：

HGNC: 10643

OMIM: 138965

KEGG: hsa:6372

STRING: 9606.ENSP00000226317

UniGene: Hs.164021

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