CTSF Antibody

說明書

中文名稱：

CTSF兔多克隆抗體
貨號：

CSB-PA006189GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UBX1
基因名：

CTSF
別名：

AI481912 antibody; CATF_HUMAN antibody; Cathepsin F antibody; CathepsinF antibody; CATSF antibody; CLN13 antibody; Ctsf antibody; EC 3.4.22.41 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CTSF
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
基因功能參考文獻：
1. The CTSF gene may function as a tumor suppressor in gastric cancer PMID: 28474574
2. Biallelic mutations in this gene have been shown to cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis with some cases resembling the impairment seen in AD. PMID: 27524508
3. Disease-causing cathepsin-F mutants fail to cleave LIMP-2. Our findings provide evidence that LIMP-2 represents an in vivo substrate of cathepsin-F with relevance for understanding the pathophysiology of type-B-Kufs-disease. PMID: 25576872
4. Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. PMID: 24255036
5. Homozygous and compound heterozygous missense mutations in CTSF are associated with adult-onset neuronal ceroid lipofuscinosis. PMID: 23297359
6. cathepsin F has a role in modifying low density lipoprotein particles PMID: 15184381
7. cathepsin F, matrix metalloproteinases 11 and 12 are upregulated in cervical cancer PMID: 15989693
8. data demonstrate a novel proatherogenic role for AngII, namely its ability to enhance secretion of lysosomal cathepsin F by monocyte-derived macrophages PMID: 16963053
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相關疾病：

Ceroid lipofuscinosis, neuronal, 13 (CLN13)
亞細胞定位：

Lysosome.
蛋白家族：

Peptidase C1 family
組織特異性：

High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.
數據庫鏈接：

HGNC: 2531

OMIM: 603539

KEGG: hsa:8722

STRING: 9606.ENSP00000310832

UniGene: Hs.11590

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