CTAGE5 Antibody

中文名稱：

CTAGE5兔多克隆抗體
貨號：

CSB-PA006131LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA006131LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CTAGE5 Polyclonal antibody
Uniprot No.：

O15320
基因名：

CTAGE5
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Endoplasmic reticulum export factor CTAGE5 protein (515-632AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CTAGE5 Antibody (CSB-PA006131LA01HU)，的標記方式是Non-conjugated。對于CTAGE5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA006131LB01HU	CTAGE5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006131LC01HU	CTAGE5 Antibody, FITC conjugated
Biotin	CSB-PA006131LD01HU	CTAGE5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
2. In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion. PMID: 27170179
3. Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases. PMID: 12586826
4. The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma. PMID: 17881540
5. population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings PMID: 20838928
6. cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII PMID: 21525241
7. HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2. PMID: 22120627
8. 22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found. PMID: 23054591
9. Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase in oral carcinoma. PMID: 23511560
10. Sec12 recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 at endoplasmic reticulum exit sites. PMID: 25202031
11. These findings define an interaction between the common MIA2(I141M) variant and the ER stress/UPR system and specify a subgroup of PDAC patients who are more likely to benefit from adjuvant chemotherapy. PMID: 25657029
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相關疾病：

Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
蛋白家族：

CTAGE family
數據庫鏈接：

HGNC: 7057

OMIM: 602132

STRING: 9606.ENSP00000280083

UniGene: Hs.287694

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