CSNK1G2 Antibody
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中文名稱：CSNK1G2兔多克隆抗體
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貨號(hào)：CSB-PA006070ESR2HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: CSNK1G2 antibody at 4.21μg/ml
Lane 1: Mouse gonadal tissue
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006070ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006070ESR2HU at dilution of 1:100 -
Immunoprecipitating CSNK1G2 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA006070ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used the Secondary antibody (1/50000)
Lane 2: CSB-PA006070ESR2HU (4μg) + Hela whole cell lysate (500μg)
Lane 3: Hela whole cell lysate (20μg)
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CSNK1G2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Casein kinase 1; gamma 2 antibody; Casein kinase I isoform gamma 2 antibody; Casein kinase I isoform gamma-2 antibody; CK1g2 antibody; CKI gamma 2 antibody; CKI-gamma 2 antibody; CSNK1G 2 antibody; Csnk1g2 antibody; KC1G2_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Mouse
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免疫原：Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC, IP
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 IP 1:200-1:2000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
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基因功能參考文獻(xiàn)：
- MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia PMID: 28885613
- MTA1s interacts with CKI-gamma2, which can phosphorylate MTA1s in an antiestrogen-dependent manner.Estrogen stimulates CKI-gamma2. CKI-gamma2 phosphorylates and modulates the functions of MTA1s. PMID: 15077195
- Data indicate that SNPs rs740423, rs2277737, rs1059684 of CSNK1G2 gene may contribute to familial febrile convulsions in children. PMID: 15300631
- Ligand-dependent ubiquitination of Smad3 is regulated by CK1g2, an inhibitor of TGF-beta signaling. PMID: 18794808
- These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT, thereby inactivating CERT and down-regulating the synthesis of sphingomyelin. PMID: 19005213
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亞細(xì)胞定位：Cytoplasm, cell cortex. Cytoplasm.
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蛋白家族：Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
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組織特異性：Testis.
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數(shù)據(jù)庫(kù)鏈接：
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