CRYAA Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CRYAA Polyclonal antibody
Uniprot No.：

P02489
基因名：

CRYAA
別名：

Acry 1 antibody; Alpha crystallin A chain antibody; Alpha-crystallin A chain antibody; CRYA 1 antibody; CRYA1 antibody; CRYAA antibody; CRYAA_HUMAN antibody; Crystallin alpha 1 antibody; Crystallin alpha A antibody; Heat shock protein beta 4 antibody; Heat shock protein beta-4 antibody; HSPB 4 antibody; HspB4 antibody; short form antibody; Zonular Central Nuclear Cataract antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Alpha-crystallin A chain protein (98-173AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Contributes to the transparency and refractive index of the lens. In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
基因功能參考文獻(xiàn)：
1. CRISPR/Cas9-mediated mutation of the alphaA-crystallin gene in rabbits recapitulates phenotypes of congenital cataracts, microphthalmia, obscurity, and early atrophy of the lens, and failed differentiation of lens fibers. PMID: 28475701
相關(guān)疾病：

Cataract 9, multiple types (CTRCT9)
亞細(xì)胞定位：

Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
蛋白家族：

Small heat shock protein (HSP20) family
組織特異性：

Expressed in the eye lens (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 2388

OMIM: 123580

KEGG: hsa:102724652

STRING: 9606.ENSP00000291554

UniGene: Hs.184085

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