CRISP2 Antibody

說明書

中文名稱：

CRISP2兔多克隆抗體
貨號：

CSB-PA005975ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: CRISP2 antibody at 12μg/ml + Rat gonad tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 32 kDa
Observed band size: 28 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005975ESR1HU at dilution of 1:100
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CRISP2 Polyclonal antibody
Uniprot No.：

P16562
基因名：

CRISP2
別名：

Cancer/testis antigen 36 antibody; CRIS2_HUMAN antibody; CRISP 2 antibody; CRISP-2 antibody; CRISP2 antibody; CT36 antibody; Cysteine rich secretory protein 2 antibody; Cysteine-rich secretory protein 2 antibody; GAPDL5 antibody; Glyceraldehyde 3 phosphate dehydrogenase like 5 antibody; Testis specific protein 1 (probe H4 1 p3 1) antibody; Testis specific protein TPX1 antibody; Testis-specific protein TPX-1 antibody; TPX1 antibody; TSP1 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Cysteine-rich secretory protein 2 protein (22-243AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
基因功能參考文獻：
1. low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males PMID: 27517483
2. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. PMID: 27161017
3. Crisp2 genetic defects in sperm from humans and mice result in male infertility. PMID: 26786179
4. Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception. PMID: 25505194
5. Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells. PMID: 23661501
6. CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins. PMID: 23027975
7. The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility. PMID: 21485539
8. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
9. TPX1 is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction. PMID: 15734896
10. The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. PMID: 16759931
11. Polymorphisms within the CRISP2 gene have no significant association with male infertility. PMID: 18550510
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亞細胞定位：

Secreted.
蛋白家族：

CRISP family
組織特異性：

Testis and epididymis.
數據庫鏈接：

HGNC: 12024

OMIM: 187430

KEGG: hsa:7180

STRING: 9606.ENSP00000339155

UniGene: Hs.2042

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