CPSF6 Antibody
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中文名稱：CPSF6兔多克隆抗體
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貨號：CSB-PA005921GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CPSF6
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別名：CFIM antibody; CFIm68 antibody; cleavage and polyadenylation specific factor 6; 68kDa antibody; Cleavage and polyadenylation specificity factor 68 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 6 antibody; cleavage factor Im complex 68 kDa subunit antibody; CPSF 68 kDa subunit antibody; Cpsf6 antibody; CPSF6_HUMAN antibody; HPBRII 4 antibody; HPBRII 7 antibody; Pre mRNA cleavage factor Im 68 kDa subunit antibody; pre-mRNA cleavage factor I; 68kD subunit antibody; pre-mRNA cleavage factor Im (68kD) antibody; Pre-mRNA cleavage factor Im 68 kDa subunit antibody; Protein HPBRII 4/7 antibody; Protein HPBRII-4/7 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CPSF6
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export.; (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).
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基因功能參考文獻：
- The authors demonstrate that CFIm functions as an enhancer-dependent activator of mRNA 3' processing. CFIm regulates global alternative polyadenylation by specifically binding and activating enhancer-containing poly(A) sites. PMID: 29276085
- High CPSF6 expression is associated with HIV infections. PMID: 29643241
- we found CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes. PMID: 28673861
- Studies suggest that binding of cleavage factor Im (CFIm) may be one of the earliest steps in promoting formation of an active cleavage complex. PMID: 27528751
- CPSF6 binding to its docking site in HIV-1 capsid leads to the recruitment of CFIm tetramer, suggesting that CFIm mediates CPSF6 function(s) in integration site targeting. PMID: 26994143
- integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 interaction drives integration into gene bodies. PMID: 26858452
- Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. PMID: 25518861
- study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo PMID: 24415937
- CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA). PMID: 22956906
- These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6. PMID: 23622145
- Loss-of-function of CFIm68 and CFIm25 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells. PMID: 23187700
- TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6. PMID: 23414560
- A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly. PMID: 23658440
- Knockdown of CF I(m)68 induced a systematic use of proximal polyadenylation sites, indicating that changes in relative abundance of a single 3' end processing factor can modulate the length of 3' untranslated regions across the transcriptome. PMID: 22813749
- A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid. PMID: 22301135
- The study reports the crystal structure of human cleavage factor I(m), comprising cleavage factor I(m)25 and the RNA recognition motif domain of cleavage factor I(m)68 kDa (CF I(m)68RRM). PMID: 21483454
- Crystal structure of CFIm25-CFIm68 RRM heterotetramer illustrated that CFIm25 homodimer is clamped by two CFIm68 monomers on each side of the dimer interface PMID: 21295486
- Structure of a CFI(m)25/CFI(m)68 RRM heterotetramer and biochemical data indicated that CFIm25 specifically recognized two UGUA elements, CFIm68 facilitates looping of the intervening RNA. CFIm-mediated RNA looping may regulate alternative polyadenylation PMID: 21295486
- HIV-1 harboring the N74D mutation in capsid protein fails to interact with CPSF6 and evades the nuclear import restriction. PMID: 20227665
- These results reveal a novel function for the pre-mRNA 3' end processing factor CF I(m)68 in mRNA export. PMID: 19864460
- Data show that cleavage factor I(m) can stimulate both cleavage and poly(adenine) addition, and can act to suppress poly(A) site cleavage in a sequence-dependent manner. PMID: 14690600
- a direct role of the U2AF 65/CF I(m) 59 interaction in the functional coordination of splicing and 3' end processing. PMID: 17024186
- CF Im68 subnuclear distribution and mobility PMID: 17267687
- Key paper demonstrating mechanism of CF Im binding to CPSF. Also challenges the long standing perception of mammalian mRNA 3'-end processing that insists that mammalian poly (A) sites are determined by two sequence elements alone. PMID: 15937220
- Elevated levels of human cleavage factor Im suppressed cleavage at the primary poly(A) site of the pre-mRNA encoding the 68 kDa subunit of CFI(m). PMID: 14690600
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亞細胞定位：Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm.
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蛋白家族：RRM CPSF6/7 family
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