COL25A1 Antibody
-
中文名稱：COL25A1兔多克隆抗體
-
貨號：CSB-PA070029
-
規格：￥1090
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：COL25A1
-
別名：COL25A1Collagen alpha-1(XXV) chain antibody; Alzheimer disease amyloid-associated protein antibody; AMY antibody; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component antibody; CLAC)] antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse
-
免疫原：Synthesized peptide derived from the Internal region of Human COL25A1.
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產品提供形式：Liquid
-
應用范圍：WB, IHC, IF, ELISA
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
-
基因功能參考文獻：
- We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
- We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
- COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
- The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
- The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
- provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
- COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
- CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
- CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
- Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
- suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410
顯示更多
收起更多
-
相關疾病：Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
-
亞細胞定位：Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
-
組織特異性：Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
