CNTN2 Antibody
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中文名稱：CNTN2兔多克隆抗體
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貨號：CSB-PA050214
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：CNTN2
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別名：Axonal glycoprotein TAG 1 antibody; Axonal glycoprotein TAG-1 antibody; Axonal glycoprotein TAG1 antibody; Axonin 1 antibody; Axonin-1 antibody; Axonin1 antibody; AXT antibody; CNTN 2 antibody; Cntn2 antibody; CNTN2_HUMAN antibody; contactin 2 (axonal) antibody; Contactin 2 antibody; Contactin-2 antibody; Contactin2 antibody; DKFZp781D102 antibody; MGC157722 antibody; TAG 1 antibody; TAG 564 antibody; TAG564 antibody; TAX 1 antibody; TAX antibody; TAX-1 antibody; TAX1 antibody; Transient axonal glycoprotein 1 antibody; Transiently expressed axonal glycoprotein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the N-terminal region of Human Contactin 2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
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基因功能參考文獻：
- the selective distribution of Caspr2 and TAG-1 may be regulated, allowing them to modulate the strategic function of the Kv1 complex along axons PMID: 28533267
- the ectodomains of CNTNAP2 and contactin 2 (CNTN2) bind directly and specifically, with low nanomolar affinity. PMID: 27621318
- RACK1 interacts with CNTN2, and the effects of RACK1 on glioma cell growth and differentiation are mediated by CNTN2. PMID: 26718491
- Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1 PMID: 24405708
- A single nucleotide deletion in exon 6 of CNTN2 results in a frameshift mutation, segregating in a recessive manner in a consanguineous Egyptian family with epilepsy. PMID: 23518707
- The single-nucleotide polymorphism (SNP) rs2275697 in the TAG-) gene was not associated with treatment responsiveness, treatment dependence, disability, or mortality in chronic inflammatory demyelinating polyneuropathy PMID: 22462668
- allelic variation in TAG-1 does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
- single nucleotide polymorphisms in TAG-1 are related to the IVIg responsiveness of Chronic inflammatory demyelinating polyneuropathy patients. PMID: 21696500
- The domains responsible for the neurite outgrowth promoting activity of TAG-1 have been investigated as well as its interactions with other cell adhesion molecules. PMID: 12139915
- TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog. PMID: 17766378
- Contactin-2 is expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides; is an autoantigen targeted by T cells and autoantibodies in MS. PMID: 19416878
- immune response to CNTN2 and possible involvement in multiple sclerosis and EAE [REVIEW] PMID: 19451620
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相關(guān)疾病：Epilepsy, familial adult myoclonic, 5 (FAME5)
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亞細胞定位：Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
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蛋白家族：Immunoglobulin superfamily, Contactin family
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數(shù)據(jù)庫鏈接：
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