CNGA2 Antibody

說明書

中文名稱：

CNGA2兔多克隆抗體
貨號：

CSB-PA599265
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA599265(CNGA2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: 293T cells, Primary antibody: CSB-PA599265(CNGA2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
其他：

產(chǎn)品詳情

Uniprot No.：

Q16280
基因名：

CNGA2
別名：

CNCA antibody; CNCA1 antibody; CNCG2 antibody; CNG 2 antibody; CNG channel alpha 2 antibody; CNG channel alpha-2 antibody; CNG-2 antibody; CNG2 antibody; CNGA 2 antibody; Cnga2 antibody; CNGA2_HUMAN antibody; Cyclic nucleotide gated cation channel 2 antibody; Cyclic nucleotide gated channel alpha 2 antibody; Cyclic nucleotide gated olfactory channel antibody; Cyclic nucleotide-gated cation channel 2 antibody; Cyclic nucleotide-gated channel alpha-2 antibody; Cyclic nucleotide-gated olfactory channel antibody; FLJ46312 antibody; OCNC1 antibody; OCNCa antibody; OCNCALPHA antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human CNGA2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
基因功能參考文獻：
1. The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease. PMID: 28572688
2. Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia. PMID: 25156905
3. The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel. PMID: 16533895
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA2 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 2149

OMIM: 300338

KEGG: hsa:1260

STRING: 9606.ENSP00000328478

UniGene: Hs.447360