CLPB Antibody

中文名稱：

CLPB兔多克隆抗體
貨號：

CSB-PA884428LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: CLPB antibody at 5μg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 79, 76, 73, 75, 58 kDa
Observed band size: 79 kDa

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA884428LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

Rabbits were immunized to generate the CLPB polyclonal antibody, which is specifically designed to recognize and bind to the human CLPB protein. The development of this antibody involved using a recombinant human CLPB protein that consisted of amino acids 1-350 as an immunogen. The resulting CLPB antibody was then purified using protein G affinity chromatography, achieving a purity level of up to 95%.

This antibody only reacts with human samples. It has been extensively tested in various experimental settings, such as ELISA, WB, and IHC, to investigate the expression, localization, and activity of the CLPB protein in different contexts. These tests have demonstrated the ability of the CLPB polyclonal antibody to effectively identify and detect the CLPB protein in various experimental conditions.
產品名稱：

Rabbit anti-Homo sapiens (Human) CLPB Polyclonal antibody
Uniprot No.：

Q9H078
基因名：

CLPB
別名：

Caseinolytic peptidase B antibody; Caseinolytic peptidase B protein homolog antibody; clpB antibody; ClpB caseinolytic peptidase B homolog (E. coli) antibody; ClpB caseinolytic peptidase B homolog antibody; CLPB_HUMAN antibody; FLJ13152 antibody; HSP78 antibody; SKD3 antibody; Suppressor of potassium transport defect 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Caseinolytic peptidase B protein homolog protein (1-350AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CLPB Antibody (CSB-PA884428LA01HU)，的標記方式是Non-conjugated。對于CLPB Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA884428LB01HU	CLPB Antibody, HRP conjugated	ELISA
FITC	CSB-PA884428LC01HU	CLPB Antibody, FITC conjugated
Biotin	CSB-PA884428LD01HU	CLPB Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6.
基因功能參考文獻：
1. The neonatal presentation of CLPB deficiency predicts the course of disease in later life, which is extremely important for counselling. PMID: 28687938
2. Case Reports: bi-allelic CLPB mutations cause cataract, renal cysts, nephrocalcinosis and 3-methylglutaconic aciduria, a novel disorder of mitochondrial protein disaggregation. PMID: 25595726
3. Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria PMID: 25650066
4. ClpB can passively thread soluble denatured proteins. PMID: 25288401
5. Mutations in CLPB define a syndrome with intellectual disability, congenital neutropenia, progressive brain atrophy, movement disorder, cataracts, and 3-methylglutaconic aciduria. PMID: 25597510
6. CLPB is proposed to function as a mitochondrial chaperone involved in disaggregation of misfolded proteins, resulting from stress such as heat denaturation. PMID: 25597511
7. ClpB-DnaK reactivated all aggregated fusion proteins with similar efficiency, without unfolding native domains, demonstrating that partial threading of the misfolded moiety is sufficient to solubilize aggregates. PMID: 18488042
8. formation of the DnaK-ClpB bichaperone network is a three step process PMID: 19698713
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相關疾病：

3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia (MEGCANN)
亞細胞定位：

Mitochondrion intermembrane space.
蛋白家族：

ClpA/ClpB family
組織特異性：

Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes.
數(shù)據(jù)庫鏈接：

HGNC: 30664

OMIM: 616254

KEGG: hsa:81570

STRING: 9606.ENSP00000294053

UniGene: Hs.523877

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