CLEC4D Antibody

中文名稱：

CLEC4D兔多克隆抗體
貨號：

CSB-PA841219LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA841219LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA841219LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CLEC4D Polyclonal antibody
Uniprot No.：

Q8WXI8
基因名：

CLEC4D
別名：

C type (calcium dependent; carbohydrate recognition domain) lectin; superfamily member 8 antibody; C type lectin domain family 4; member D antibody; C type lectin like receptor 6 antibody; C type lectin receptor antibody; C type lectin superfamily member 8 antibody; C-type lectin domain family 4 member D antibody; C-type lectin superfamily member 8 antibody; C-type lectin-like receptor 6 antibody; CLC4D_HUMAN antibody; CLEC 6 antibody; CLEC-6 antibody; Clec4d antibody; CLEC6 antibody; CLECSF8 antibody; lectin; C type; superfamily member 8 antibody; Macrophage C type lectin antibody; MCL antibody; MGC40078 antibody; MPCL antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human C-type lectin domain family 4 member D protein (39-215AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CLEC4D Antibody (CSB-PA841219LA01HU)，的標記方式是Non-conjugated。對于CLEC4D Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA841219LB01HU	CLEC4D Antibody, HRP conjugated	ELISA
FITC	CSB-PA841219LC01HU	CLEC4D Antibody, FITC conjugated
Biotin	CSB-PA841219LD01HU	CLEC4D Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.
基因功能參考文獻：
1. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants. PMID: 24101491
2. CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule PMID: 22689578
3. Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor. PMID: 14971047
亞細胞定位：

Cell membrane; Single-pass type II membrane protein.
組織特異性：

Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.
數據庫鏈接：

HGNC: 14554

OMIM: 609964

KEGG: hsa:338339

STRING: 9606.ENSP00000299665

UniGene: Hs.351811

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