CLEC16A Antibody
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中文名稱：CLEC16A兔多克隆抗體
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貨號：CSB-PA288812
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA288812(CLEC16A Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA288812(CLEC16A Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：CLEC16A
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別名：CLEC16A antibody; KIAA0350Protein CLEC16A antibody; C-type lectin domain family 16 member A antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human CLEC16A
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
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基因功能參考文獻：
- Golgi-associated CLEC16A negatively regulates autophagy via modulation of mTOR activity. PMID: 28223137
- Study provides evidence that Clec16a plays a key role in the survival of Purkinje cells and in the degradative function or clearance of autolysosomes. PMID: 26987296
- A possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A. PMID: 26203907
- CLEC16A was found to be a susceptibility factor for SLE, with possible contribution to the development of the disease. PMID: 26121298
- Clec16a knockdown mice showed reduced number of B cells and elevated IgM levels compared with controls. PMID: 25891430
- identify CLEC16A as a pivotal gene in multiple sclerosis that serves as a direct regulator of the human leukocyte antigen class II pathway in antigen-presenting cells. PMID: 25823473
- data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men. PMID: 25447402
- This study demonstrated that the Polymorphism, Single Nucleotide of CLEC16A is associated with multiple sclerosis in Russia. PMID: 25903733
- The study suggested that a CLEC16A polymorphism may be protective against Vogt-Koyanagi-Harada syndrome syndrome in a Chinese Han population. PMID: 25576669
- Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs. PMID: 24646814
- Forty-eight SNPs, all located in CLEC16A, provided a statistically significant association with type 1 diabetes mellitus, with rs34306440 being most significantly associated. The mechanisim is likely through reduced expression of DEXI transcripts. PMID: 25008175
- Study demonstrates that a diabetogenic SNP in the CLEC16A locus correlates with islet CLEC16A expression, beta cell function, and glycemic control in human subjects. Clec16a controls beta cell function and prevents diabetes by controlling mitophagy. PMID: 24949970
- The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI. PMID: 23151489
- Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women PMID: 23133532
- Genome-wide significant association was found for rs20541 and rs998592, thus establishing IL-13 and KIAA0350/CLEC16A as susceptibility loci for alopecia areata. IL-13 and KIAA0350/CLEC16A are also susceptibility loci for other autoimmune diseases. PMID: 22534877
- Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis. PMID: 22257840
- A significant association with multiple sclerosis is found for four single nucleotide polymorphisms within the CLEC16A gene, all located in the same linkage disequilibrium (LD) block. PMID: 20849399
- Data show independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex in multiple sclerosis susceptibility. PMID: 21653641
- Expression analysis revealed that rs12708716 genotype was significantly associated with the relative expression levels of two different CLEC16A transcripts in thymus (P=0.004) PMID: 21179112
- Results show that CLEC16A does not have a prominent function in susceptibility to anti-cyclic citrullinated peptide (CCP)-positive rheumatoid arthritis. PMID: 20220768
- Studies indicate that SNP in IL7RA, IL2RA, CD58 and CLEC16A genes has been consistently associated with MS. PMID: 20450971
- SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
- A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis PMID: 19734133
- The initial chi-square test revealed that the Cright curved arrow T polymorphism of CLEC16A and the Aright curved arrow G polymorphism of SPTBN5 were significantly ssociated with ischemic stroke among individuals with metabolic syndrome. PMID: 20043139
- Studies indicate that five SNPs showed genome-wide significant association with MS: HLA-DRA, IL7R, IL2RA, CD58 and CLEC16A. PMID: 19834503
- results indicate that KIAA0350 might be involved in the pathogenesis of type 1 diabetes and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits PMID: 17632545
- Two alleles at 16p13 are independently associated with the risk of Addison's disease in the Norwegian population, suggesting this chromosomal region to harbor common autoimmunity gene(s), CLEC16A and CIITA being possible independent candidates. PMID: 18593762
- There is evidence of a genome-wide significant association between KIAA0350 and risk of multiple sclerosis in Australians. PMID: 18650830
- Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Italy. PMID: 18946483
- CLEC16A is a multiple sclerosis susceptibility gene. PMID: 18987646
- The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to type 1 diabetes in the Chinese population. PMID: 19178520
- Autoimmune disease association signals in KIAA0350 are not involved in celiac disease susceptibility PMID: 19317741
- a CLEC16A/KIAA0350 polymorphism may have a role in NOD2/CARD15(-) Crohn's disease patients PMID: 19337309
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相關疾病：Diabetes mellitus, insulin-dependent (IDDM)
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亞細胞定位：Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
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蛋白家族：CLEC16A/gop-1 family
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組織特異性：Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells.
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數據庫鏈接：
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