CLDN8 Antibody
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中文名稱：CLDN8兔多克隆抗體
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貨號：CSB-PA104901
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells, using CLDN8 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CLDN8 Polyclonal antibody
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Uniprot No.：
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基因名：CLDN8
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別名：CLDN8; UNQ779/PRO1573; Claudin-8
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human CLDN8.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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基因功能參考文獻：
- the present study revealed the distinct expression profiles of claudin5, 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma PMID: 29901188
- data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine PMID: 29145422
- these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer PMID: 28474805
- Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway. PMID: 27029486
- High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma. PMID: 26560196
- the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues. PMID: 26464708
- Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
- claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma PMID: 18799195
- Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon. PMID: 19000657
- the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas. PMID: 19302533
- CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707
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亞細胞定位：Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
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蛋白家族：Claudin family
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組織特異性：Expressed in the epididymis, mainly in the caput segment.
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數據庫鏈接：
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