CIAO3 Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NARFL Polyclonal antibody
Uniprot No.：

Q9H6Q4
基因名：

NARFL
別名：

CIAO3 antibody; NARFL antibody; PRNCytosolic iron-sulfur assembly component 3 antibody; Cytosolic Fe-S cluster assembly factor NARFL antibody; Iron-only hydrogenase-like protein 1 antibody; IOP1 antibody; Nuclear prelamin A recognition factor-like protein antibody; Protein related to Narf antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Cytosolic iron-sulfur assembly component 3 protein (2-265AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
基因功能參考文獻(xiàn)：
1. we concluded that the Ser161Ile mutant induced NARFL deficiency and eventually diffuse PAVMs probably through VEGF pathway. In a word, we detected a functional mutation in NARFL, which might be the pathogenic gene in this pedigree. PMID: 27835862
2. IOP1 is involved in mammalian cytosolic Fe-S protein maturation. PMID: 18270200
3. human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1. PMID: 19864422
蛋白家族：

NARF family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 14179

OMIM: 611118

KEGG: hsa:64428

STRING: 9606.ENSP00000251588

UniGene: Hs.513247

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