CHST3 Antibody

中文名稱：

CHST3兔多克隆抗體
貨號：

CSB-PA759175LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA759175LA01HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA759175LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CHST3 Polyclonal antibody
Uniprot No.：

Q7LGC8
基因名：

CHST3
別名：

C6ST 1 antibody; C6ST antibody; C6ST-1 antibody; C6ST1 antibody; Carbohydrate (chondroitin 6) sulfotransferase 3 antibody; Carbohydrate sulfotransferase 3 antibody; Chondroitin 6 O sulfotransferase 1 antibody; Chondroitin 6 sulfotransferase antibody; Chondroitin 6-O-sulfotransferase 1 antibody; Chondroitin 6-sulfotransferase antibody; CHST 3 antibody; Chst3 antibody; CHST3_HUMAN antibody; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 0 antibody; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 antibody; GST 0 antibody; GST-0 antibody; GST0 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Carbohydrate sulfotransferase 3 protein (316-427AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CHST3 Antibody (CSB-PA759175LA01HU)，的標記方式是Non-conjugated。對于CHST3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA759175LB01HU	CHST3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA759175LC01HU	CHST3 Antibody, FITC conjugated
Biotin	CSB-PA759175LD01HU	CHST3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
基因功能參考文獻：
1. We describe three consanguineous Indian families with a distinct form of spondyloepiphyseal dysplasia (SED Omani type). It is an autosomal recessive disorder due to mutation in CHST3 gene. PMID: 27753269
2. A novel CHST3 allele associated with spondyloepiphyseal dysplasia and hearing loss has been described in a consanguineous Pakistani pedigree. PMID: 26572954
3. Sequencing of CHST3 detected a previously unreported homozygous duplication c.407_426dup (p.Thr143Cysfs*80). The mutation is predicted to lead to frameshift and introduction of a premature stopcodon. PMID: 24300290
4. expression of CHST3 mRNA was significantly reduced in the intervertebral disc cells of subjects carrying the A allele of rs4148941 PMID: 24216480
5. The results of this study indicated that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons. PMID: 22246436
6. Vertebral changes, normal carpal age, lack of facial flattening, and recessive inheritance are characteristic and distinguishes CHST3 deficiency from other disorders with congenital dislocations. PMID: 20830804
7. report eight CHST3 mutations in six unrelated individuals who presented at birth with congenital joint dislocations PMID: 18513679
8. Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. PMID: 18697746
9. homozygous missense mutation (T141M) in exon 3 in all three family members with spondyloepiphyseal dysplasia with cardiac involvement PMID: 19320654
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相關疾病：

Spondyloepiphyseal dysplasia with congenital joint dislocations (SEDCJD)
亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily
組織特異性：

Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.
數據庫鏈接：

HGNC: 1971

OMIM: 143095

KEGG: hsa:9469

STRING: 9606.ENSP00000362207

UniGene: Hs.158304

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