CHRNA10 Antibody

說明書

中文名稱：

CHRNA10兔多克隆抗體
貨號：

CSB-PA000800
規格：

￥1090
圖片：
Western Blot analysis of A549 cells using AChRα10 Polyclonal Antibody

Western Blot analysis of HuvEc MCF7 cells using AChRα10 Polyclonal Antibody
其他：

產品詳情

Uniprot No.：

Q9GZZ6
基因名：

CHRNA10
別名：

Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit antibody; ACH10_HUMAN antibody; Alpha 10 nAChR antibody; Cholinergic receptor nicotinic alpha 10 antibody; Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10 antibody; Cholinergic receptor, nicotinic, alpha polypeptide 10 antibody; CHRNA 10 antibody; CHRNA10 antibody; NACHR alpha 10 antibody; NACHR alpha-10 antibody; NACHRA10 antibody; Neuronal acetylcholine receptor protein subunit alpha 10 antibody; Neuronal acetylcholine receptor subunit alpha-10 antibody; Nicotinic acetylcholine receptor subunit alpha 10 antibody; Nicotinic acetylcholine receptor subunit alpha-10 antibody; OTTHUMP00000013620 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the C-terminal region of Human AChRα10.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
基因功能參考文獻：
1. A two order of magnitude species difference is reported in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR. PMID: 22774872
2. CHRNA10 may have a role in "dizziness" in response to tobacco PMID: 19760673
亞細胞定位：

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-10/CHRNA10 sub-subfamily
組織特異性：

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
數據庫鏈接：

HGNC: 13800

OMIM: 606372

KEGG: hsa:57053

STRING: 9606.ENSP00000250699

UniGene: Hs.732806

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