CEP57 Antibody
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中文名稱：CEP57兔多克隆抗體
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貨號：CSB-PA095230
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from LOVO cells and COLO cells, using MRPS7 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CEP57 Polyclonal antibody
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Uniprot No.：
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基因名：CEP57
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from internal of Human CEP57.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.
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基因功能參考文獻(xiàn)：
- Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 complex/Ndc80 complex) network and spindle assembly checkpoint via Mis12 binding and Mad1-Mad2 interaction. PMID: 26743940
- We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter PMID: 26561035
- Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
- Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
- Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. PMID: 23243019
- Cep57 acts as a PCM component through binding to NEDD1 and is required for spindle microtubule organization and maintenance of spindle pole integrity. PMID: 22508265
- Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division. PMID: 21552266
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相關(guān)疾病：Mosaic variegated aneuploidy syndrome 2 (MVA2)
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亞細(xì)胞定位：Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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蛋白家族：Translokin family
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組織特異性：Ubiquitous.
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數(shù)據(jù)庫鏈接：
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