CELF4 Antibody
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中文名稱：CELF4兔多克隆抗體
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貨號：CSB-PA883643LA01HU
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規格：￥440
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圖片：
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IHC image of CSB-PA883643LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CELF4 Polyclonal antibody
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Uniprot No.：
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基因名：CELF4
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別名：CELF4 antibody; BRUNOL4 antibody; CUGBP Elav-like family member 4 antibody; CELF-4 antibody; Bruno-like protein 4 antibody; CUG-BP- and ETR-3-like factor 4 antibody; RNA-binding protein BRUNOL-4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human CUGBP Elav-like family member 4 protein (120-236AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，CELF4 Antibody (CSB-PA883643LA01HU)，的標記方式是Non-conjugated。對于CELF4 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
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基因功能參考文獻：
- The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders. PMID: 28407444
- Authors report a modifying effect of a polymorphism of CELF4 on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants. PMID: 26811534
- Determination of CELF4 protein domains required for RNA splicing. PMID: 14973222
- validated occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：CELF/BRUNOL family
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組織特異性：Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.
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數據庫鏈接：
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