CDKN3 Antibody

中文名稱：

CDKN3兔多克隆抗體
貨號：

CSB-PA005096LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005096LA01HU at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA005096LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CDKN3 Polyclonal antibody
Uniprot No.：

Q16667
基因名：

CDKN3
別名：

CDI1 antibody; Cdk associated protein phosphatase antibody; CDK2 associated dual specificity phosphatase antibody; CDK2-associated dual-specificity phosphatase antibody; CDKN3 antibody; CDKN3_HUMAN antibody; CIP2 antibody; Cyclin dependent kinase inhibitor 3 antibody; Cyclin dependent kinase interacting protein 2 antibody; Cyclin dependent kinase interactor 1 antibody; Cyclin-dependent kinase inhibitor 3 antibody; Cyclin-dependent kinase interactor 1 antibody; Cyclin-dependent kinase-interacting protein 2 antibody; FLJ25787 antibody; KAP antibody; KAP1 antibody; Kinase associated phosphatase antibody; Kinase-associated phosphatase antibody; MGC70625 antibody; OTTHUMP00000178991 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cyclin-dependent kinase inhibitor 3 protein (1-172AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CDKN3 Antibody (CSB-PA005096LA01HU)，的標記方式是Non-conjugated。對于CDKN3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA005096LB01HU	CDKN3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005096LC01HU	CDKN3 Antibody, FITC conjugated
Biotin	CSB-PA005096LD01HU	CDKN3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
基因功能參考文獻：
1. Results demonstrate that upregulation of p27 is involved in the knockdown of CDKN3-induced decrease in cell proliferation, increase in cell cycle arrest and apoptosis, decrease in invasion, and increase in radiosensitivity. PMID: 28109073
2. the mechanism of CDKN3 overexpression in human cancer PMID: 28504190
3. CDKN3 is frequently upregulated in gastric cancer tissues and cell lines and is related to advanced clinical stage, recurrence, and poor clinical outcome in gastric cancer. The functional data strongly suggest that CDKN3 behaves as an oncogene in gastric cancer, and downregulation of CDKN3 could inhibit gastric cancer cell proliferation, migration, and invasion, and induce cell cycle arrest and apoptosis. PMID: 27983933
4. CDKN3 may act as a tumor suppressor in liver tissues by modulation of the cell survival signal transduction, monitoring carcinogenesis and elimination of abnormal cells. PMID: 27314282
5. These results suggest that CDKN3 acts as an oncogene during breast cancer progression. The in vitro silencing of CDKN3 promoted apoptosis, induced G1 phase cell cycle arrest and inhibited cell migration. PMID: 27314680
6. Knockdown of Cdkn3 stabilizes Mps1 at centrosomes. PMID: 26586430
7. CDKN3 mRNA may be a good survival biomarker and potential therapeutic target in cervical cancer PMID: 26372210
8. CDKN3 overexpression in lung adenocarcinoma is not attributed to alternative splicing or mutation but is likely due to increased mitotic activity, arguing against CDKN3 as a tumour suppressor PMID: 26554648
9. CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer cells. PMID: 26191143
10. These results highlight the importance of CDKN3 in Bcr-Abl-mediated leukemogenesis. PMID: 25360622
11. High CDKN3 expression is associated with colorectal cancer. PMID: 25735390
12. these data identify KAP as a major regulator of cell division via interactions with numerous target proteins. aberrant splicing or miR-26a decreases KAP expression to promote glioblastoma growth and invasion. PMID: 24704824
13. CDKN3 may play an important role in the development and proliferation of epithelial ovarian cancer PMID: 24573179
14. KAP is overexpressed in alcohol-related hepatocellular carcinoma. PMID: 23292002
15. RelB activation is key for promoting multiple myeloma cell survival through the upregulation of anti-apoptotic proteins, in particular, CIAP2. PMID: 23555623
16. CDKN3 controls mitosis through the CDC2 signaling axis. PMID: 23775190
17. High CDKN3 expression is associated with cervical cancer. PMID: 23405241
18. cyclin-dependent kinase-associated protein phosphatase expression was associated with poorly differentiated Renal cell carcinoma PMID: 21396835
19. These results suggest that CDKN3 acts as an oncogene in human hepatocellular carcinoma and antagonism of CDKN3 may be of interest for the treatment of HCC. PMID: 22390936
20. analysis of CDKN3 cell cycle networks and the molecular mechanism of non-malignancy associated hepatitis/cirrhosis and HCC transformation PMID: 21535270
21. Identification of a KAP domain that interacts with cyclin-dependent kinase 2. PMID: 12745075
22. In choline-deficient neuroblastoma cells, the promoter of the cyclin-dependent kinase inhibitor 3 gene (CDKN3) was hypomethylated. This was associated with increased expression of CDKN3 gene product kinase-associated phosphatase (KAP) PMID: 15147518
23. Pax3 represses transcription through a novel mechanism involving competition between corepressor KAP1 and the heterochromatin-binding protein HP1gamma PMID: 16945326
24. the reduction of KAP1 levels promotes p53-dependent p21 induction and inhibits cell proliferation in actinomycin D-treated cells. PMID: 17056014
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相關疾病：

Hepatocellular carcinoma (HCC)
亞細胞定位：

Cytoplasm, perinuclear region.
蛋白家族：

Protein-tyrosine phosphatase family
數據庫鏈接：

HGNC: 1791

OMIM: 114550

KEGG: hsa:1033

STRING: 9606.ENSP00000335357

UniGene: Hs.84113

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