CDK2AP2 Antibody

說(shuō)明書

產(chǎn)品詳情

Uniprot No.：

O75956
基因名：

CDK2AP2
別名：

CDK2AP2 antibody; DOC1RCyclin-dependent kinase 2-associated protein 2 antibody; CDK2-associated protein 2 antibody; DOC-1-related protein antibody; DOC-1R antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human DOC-1R.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A.
基因功能參考文獻(xiàn)：
1. Our findings suggest that alteration of p16, p14, p27, p21, and p53 status may contribute to carcinogenesis and the clinical behavior of HPV-negative adenocarcinoma of the uterine cervix PMID: 25675191
2. antitumor effects of DOC-1R may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 expression and activation PMID: 23781148
亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

CDK2AP family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 30833

KEGG: hsa:10263

STRING: 9606.ENSP00000301488

UniGene: Hs.523835

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