CDC42BPB Antibody

中文名稱：

CDC42BPB兔多克隆抗體
貨號：

CSB-PA22709A0Rb
規格：

￥440
圖片：
IHC image of CSB-PA22709A0Rb diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22709A0Rb diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA22709A0Rb at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CDC42BPB Polyclonal antibody
Uniprot No.：

Q9Y5S2
基因名：

CDC42BPB
別名：

CDC42 binding protein kinase beta antibody; CDC42-binding protein kinase beta antibody; CDC42BPB antibody; DMPK like beta antibody; DMPK-like beta antibody; KIAA1124 antibody; MRCK beta antibody; MRCKB_HUMAN antibody; Myotonic dystrophy kinase related CDC42 binding kinase beta antibody; Myotonic dystrophy kinase-related CDC42-binding kinase beta antibody; Myotonic dystrophy protein kinase like beta antibody; Myotonic dystrophy protein kinase-like beta antibody; Serine/threonine protein kinase MRCK beta antibody; Serine/threonine-protein kinase MRCK beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase MRCK beta protein (1609-1711AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CDC42BPB Antibody (CSB-PA22709A0Rb)，的標記方式是Non-conjugated。對于CDC42BPB Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA22709B0Rb	CDC42BPB Antibody, HRP conjugated	ELISA
FITC	CSB-PA22709C0Rb	CDC42BPB Antibody, FITC conjugated
Biotin	CSB-PA22709D0Rb	CDC42BPB Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
基因功能參考文獻：
1. these results provide further validation for MRCK involvement in regulation of cancer cell invasion. PMID: 21949762
2. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. PMID: 21240187
3. Q-PCR results demonstrated VH2 genes were overexpressed in ankylosing spondylitis patients. The sequence analysis revealed the majority of them contained CDC42 binding protein kinase Beta (CDC42 BPB) genes. PMID: 20177145
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell projection, lamellipodium.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
組織特異性：

Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
數據庫鏈接：

HGNC: 1738

OMIM: 614062

KEGG: hsa:9578

STRING: 9606.ENSP00000355237

UniGene: Hs.654634

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