CDAN1 Antibody

中文名稱：

CDAN1兔多克隆抗體
貨號：

CSB-PA810285LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of SH-SY5Y cells with CSB-PA810285LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CDAN1 Polyclonal antibody
Uniprot No.：

Q8IWY9
基因名：

CDAN1
別名：

CDA1 antibody; CDAI antibody; CDAN1 antibody; CDAN1_HUMAN antibody; Codanin antibody; Codanin-1 antibody; Codanin1 antibody; PRO1295 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Codanin-1 protein (62-249AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，CDAN1 Antibody (CSB-PA810285LA01HU)，的標(biāo)記方式是Non-conjugated。對于CDAN1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA810285LB01HU	CDAN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA810285LC01HU	CDAN1 Antibody, FITC conjugated
Biotin	CSB-PA810285LD01HU	CDAN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

May act as a negative regulator of ASF1 in chromatin assembly.
基因功能參考文獻(xiàn)：
1. Mutation in CDAN1 gene is associated with congenital dyserythropoietic anemia. PMID: 29031773
2. The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. PMID: 23716552
3. The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. PMID: 24196372
4. The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. PMID: 22407294
5. A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. PMID: 21364188
6. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 PMID: 12434312
7. codanin-1 may play a role in the development of the skeleton. PMID: 16767397
8. This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. PMID: 18081704
9. Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. PMID: 18575862
10. Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. PMID: 19336738
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相關(guān)疾病：

Anemia, congenital dyserythropoietic, 1A (CDAN1A)
亞細(xì)胞定位：

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.
組織特異性：

Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
數(shù)據(jù)庫鏈接：

HGNC: 1713

OMIM: 224120

KEGG: hsa:146059

STRING: 9606.ENSP00000348564

UniGene: Hs.599232

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