CD83 Antibody

說明書

中文名稱：

CD83兔多克隆抗體
貨號：

CSB-PA001478
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using CD83 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q01151
基因名：

CD83
別名：

CD83; CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human CD83.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
基因功能參考文獻：
1. the presence of CD83 in mDC membranes enhances T lymphocyte proliferation by boosting calcium release from intracellular stores in these cells. PMID: 24436459
2. this study shows that the tolerogenic mechanism of action of sCD83 to be dependent on initial interaction with antigen-presenting cells, altering early cytokine signal pathways and leading to T cell unresponsiveness PMID: 28193829
3. this study shows differential expression and function of CD83 on human immune cells, and reveals potential new roles for this molecule as a target of therapeutic manipulation in transplantation, inflammation, and autoimmune diseases PMID: 27837105
4. We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites PMID: 27702941
5. Crystal structure of human CD83 reveals that its surface domain consists of an Ig-like domain only.CD83 exerts its immunological activity by mixed homotypic and heterotypic interactions as typically observed for proteins present in the immunological synapse. PMID: 28315353
6. this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD83 PMID: 27421624
7. Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2. PMID: 26561569
8. nonspreading Rift Valley fever virus infection of monocyte-derived immature denditic cells results in incomplete maturation, associated with gradual downregulation of CD83. PMID: 26575844
9. Sustained expression of CD83 was observed when CD4+ T cells were induced by transforming growth factor-beta to differentiate into CD4+CD25+ forkhead box P3+ regulatory T (iTreg) cells. PMID: 25997495
10. These results suggest that HTLV-I induces CD83 expression on T cells via Tax1 -mediated NF-kappaB activation, which may promote HTLV-I infection in vivo. PMID: 26129803
11. CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. PMID: 25151500
12. GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation and that this interaction plays a role in CD83 glycosylation as well as in surface expression of CD83 on dendritic cells. PMID: 25701785
13. suggesting that a negative feedback regulation may exist in monocyte differentiation into dendritic cells (DCs) based on sCD83 released from the mature DCs PMID: 25243645
14. IDO and CD83 are expressed differently in human epidermal Langerhans cells PMID: 24268989
15. HSV-1 ICP0 alone induces CD83 degradation independent of its E3 ubiquitin ligase function and of the ubiquitin machinery. PMID: 24643878
16. Data indicate that the frequencies of CD11c, CD11c/CD86, HLA-DR/CD86, CD83 and CD80 were significantly high, while CD11c/HLA-DR was low in Hepatitis E infection. PMID: 23246582
17. We identified IRF-1, IRF-2, IRF-5, p50, p65, and cRel to be involved in regulating maturation-specific CD83 expression in DCs. PMID: 23339870
18. Results do not suggest that the common genetic variation of CD83 is related to cervical or vulvar cancers. The association between tagSNP rs853360 and risk of cervical SCC is likely to be due to chance. PMID: 22134374
19. CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2 PMID: 22065790
20. Suggest that impaired immune function, absence of CD83-positive mature and activated dendritic cells in cancer nodules may have a role in the pathogenesis of thyroid papillary carcinoma. PMID: 21469977
21. No CD83-positive Langerhans cells were detected in any epidermodysplasia verruciformis patients or normal controls. PMID: 19317050
22. Human solublee CD83 alone is capable of inducing kidney allograft tolerance in kidney transplantation in mice. PMID: 21076370
23. Structure identification of recombinant CD83 mutant variant as a potent therapeutic protein is reported. PMID: 20566323
24. sCD83 is capable of attenuating dendritic cell maturation and function, and inducing donor-specific allograft tolerance, in the absence of toxicity. PMID: 20861805
25. Data show that pollen grains triggered the production of IL-8, TNF-alpha, IL-6 and strongly upregulated the membrane expression of CD80, CD86, CD83, HLA-DR and caused only a slight increase in the expression of CD40. PMID: 20118277
26. Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. PMID: 19257981
27. the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83. PMID: 12072358
28. cloning and characterization of the promoter region of the human CD83 gene PMID: 12182451
29. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease PMID: 12594843
30. induction of the CD83 promoter by LMP1 of Epstein-barr virus is mediated by the activation of NF-kappaB signal pathway in B cells PMID: 12857898
31. 20% of chronic lymphocytic leukemia & 5/7 mantle-cell lymphoma patients have significantly elevated levels of soluble CD83. sCD83 may have an immunoregulatory role in vivo & functional significance in hematological malignancies, like CLL and MCL. PMID: 14687618
32. infected mature monocyte-derived dendritic cells lose surface CD83 while maintaining intracellular protein expression in cytomegalovirus infection. PMID: 14962896
33. monocytes, macrophages and immature DCs contain preformed intracellular CD83, and its rapid surface expression upon activation is post-translationally regulated in a process involving glycosylation PMID: 15320871
34. combined treatment of phosphatidic acid and tumor necrosis factor-alpha induce expression of CD83 in KG1 cells. PMID: 15454113
35. analysis of monomeric and dimeric isoforms of CD83 PMID: 15721284
36. Putative soluble forms of CD83 proteins are characterized by a partial deletion of the extracellular and transmembrane domains; the smallest CD83 splice product shows a strong inhibitory effect on T cell proliferation in mixed leukocyte reactions. PMID: 15905506
37. Results suggest the importance of tumor-infiltrating CD83(+) dendritic cells as a useful prognostic factor for patients with gallbladder carcinoma. PMID: 16012714
38. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86 PMID: 17197902
39. HSV-1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome PMID: 17428858
40. The abundance of CD83+ plasmacytoid dendritic cells (DCs) in perivascular areas and the overexpression of CCL19 and CCL21 in perivascular cellular foci suggest plasmacytoid DCs are central to the muscle inflammation in juvenile dermatomyositis. PMID: 17469160
41. CD83 antigen was identified as a useful tumor marker for the diagnosis of pediatric large cell lymphoma. PMID: 17535098
42. mRNA can be measured by real-time polymerase chain reaction to determine removal of dendritic cells in whole blood PMID: 17561858
43. membrane expression of the dendritic cell maturation marker CD83 on tumor cells from lung cancer patients PMID: 17628801
44. CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer PMID: 18056445
45. In rheumatoid arthritis patients, the number of CD304(+) plasmacytoid DCs (pDCs) exceeded that of CD1c(+) myeloid DCs (mDCs), with the majority of infiltrating DCs being CD83(-) or DC-LAMP(-). PMID: 18292234
46. Data suggest that in systemic lupus erythematosus, the increased number of plasmacytoid dendritic cells (DCs) supports a pathogenic role for these cells, and decreased myeloid DC and CD83 expression may explain susceptibility to infections. PMID: 18625638
47. GM-CSF can both synergize with TNFalpha in the case of expression of IL1-RA and antagonize in the case of CD83. PMID: 18755511
48. The CK2 alpha' phosphorylates APRIL and therefore is responsible for the regulation of the nucleocytoplasmic translocation of CD83 mRNA. PMID: 19130553
49. sCD83 release may play a regulatory role in CLL progression. PMID: 19195701
50. Overexpression of CD83 in transgenic mice suppresses the humoral response to both T cell-independent and T-cell dependent model antigens in a dose-dependent manner. PMID: 19234177
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.
數據庫鏈接：

HGNC: 1703

OMIM: 604534

KEGG: hsa:9308

STRING: 9606.ENSP00000368450

UniGene: Hs.595133

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